{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Wang Y"],"pubmed_abstract":["Objective
To explore the significance of modeled CA-125 elimination rate constant (KELIM) in predicting satisfactory cytoreduction at interval debulking surgery (IDS), survival prognosis, and platinum-based chemosensitivity in patients with advanced ovarian cancer treated with neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS).Methods
The clinical information and follow-up data of 70 patients with advanced ovarian cancer who underwent NACT-IDS in the Department of Gynecology of Dalian Central Hospital from January 2010 to June 2023 were retrospectively analyzed. The KELIM for each patient during neoadjuvant chemotherapy was calculated using the online calculation tool (https://www.biomarker-kinetics.org/CA-125-neo), and its predictive value for IDS s"],"journal":["Frontiers in oncology"],"pagination":["1677070"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12832227"],"repository":["biostudies-literature"],"pubmed_title":["Predictive value of the KELIM in neoadjuvant treatment for patients with advanced ovarian cancer."],"pmcid":["PMC12832227"],"pubmed_authors":["Bian P","Yang Y","Wang Y","Yuan H","Wang J","Yu Y","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Predictive value of the KELIM in neoadjuvant treatment for patients with advanced ovarian cancer.","description":"Objective
To explore the significance of modeled CA-125 elimination rate constant (KELIM) in predicting satisfactory cytoreduction at interval debulking surgery (IDS), survival prognosis, and platinum-based chemosensitivity in patients with advanced ovarian cancer treated with neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS).Methods
The clinical information and follow-up data of 70 patients with advanced ovarian cancer who underwent NACT-IDS in the Department of Gynecology of Dalian Central Hospital from January 2010 to June 2023 were retrospectively analyzed. The KELIM for each patient during neoadjuvant chemotherapy was calculated using the online calculation tool (https://www.biomarker-kinetics.org/CA-125-neo), and its predictive value for IDS s","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-17T04:56:44.416Z","creation":"2026-06-17T03:06:58.7Z"},"accession":"S-EPMC12832227","cross_references":{"pubmed":["41602373"],"doi":["10.3389/fonc.2025.1677070"]}}