{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Zhang R"],"pubmed_abstract":["<h4>Background</h4>Cognitive stimulation therapy (CST) and its maintenance phase (MCST) can benefit dementia. We evaluated treatment-effect heterogeneity by euthyroid versus subclinical hypothyroidism/hyperthyroidism during the 16-week maintenance period following CST.<h4>Methods</h4>We conducted a prospective single-center cohort embedded in routine CST to MCST. All entrants to 7-week CST were assessed at baseline/8/16/24 weeks. Sixteen-week MCST occurred per usual care. Baseline TSH/FT4/FT3 are classified as euthyroid, subclinical hypothyroidism (SCH), or hyperthyroidism (SHyper). Co-primary outcomes were 24-week Montreal Cognitive Assessment (MoCA) and Zarit changes. We used doubly robust inverse-probability-of-treatment weighting combined with linear mixed-effects models to test MCST×t"],"journal":["Frontiers in neurology"],"pagination":["1710962"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12832453"],"repository":["biostudies-literature"],"pubmed_title":["Thyroid function status and heterogeneity of efficacy of maintenance cognitive stimulation in late-life dementia: a stratified observational study of subclinical hypothyroidism/hyperthyroidism."],"pmcid":["PMC12832453"],"pubmed_authors":["Li X","Yang J","Yang L","Wang S","Li F","Jia B","Zhou Y","Xu X","Zhang R","Yu H","Yu X","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"Thyroid function status and heterogeneity of efficacy of maintenance cognitive stimulation in late-life dementia: a stratified observational study of subclinical hypothyroidism/hyperthyroidism.","description":"<h4>Background</h4>Cognitive stimulation therapy (CST) and its maintenance phase (MCST) can benefit dementia. We evaluated treatment-effect heterogeneity by euthyroid versus subclinical hypothyroidism/hyperthyroidism during the 16-week maintenance period following CST.<h4>Methods</h4>We conducted a prospective single-center cohort embedded in routine CST to MCST. All entrants to 7-week CST were assessed at baseline/8/16/24 weeks. Sixteen-week MCST occurred per usual care. Baseline TSH/FT4/FT3 are classified as euthyroid, subclinical hypothyroidism (SCH), or hyperthyroidism (SHyper). Co-primary outcomes were 24-week Montreal Cognitive Assessment (MoCA) and Zarit changes. We used doubly robust inverse-probability-of-treatment weighting combined with linear mixed-effects models to test MCST×t","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-15T06:25:38.248Z","creation":"2026-06-15T03:08:56.489Z"},"accession":"S-EPMC12832453","cross_references":{"pubmed":["41602965"],"doi":["10.3389/fneur.2025.1710962"]}}