biostudies-literatureUnknownLee DIntramural NIH HHSNIA NIH HHSNIH HHSNeurodegenerative and neuropsychiatric diseases impose a significant societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited. To gain deeper insights into the etiology of different brain diseases, we used specimens from 1,494 unique donors to generate a population-scale single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex (DLPFC), comprising over 6.3 million individual nuclei. The cohort includes neurotypical controls as well as donors affected by eight common and complex brain disorders: Alzheimer's disease (AD), diffuse Lewy body disease (DLBD), vascular dementia (Vas), Parkinson's disease (PD), tauopathy, frontotemporal dementia, schizophrenia, and bipolar disorder. We shmedRxiv : the preprint server for health sciences2024.10.31.24316513https://www.ebi.ac.uk/biostudies/studies/S-EPMC12833908biostudies-literatureSingle-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseases.PMC12833908ZIC MH002903U01 AG061356R01 AG015819P30 AG072975R01 AG067025U01 AG046152R01 AG06558275N95019C00049R01 AG082185R01 AG022018P30 AG010161R01 AG017917Barnes LLAuluck PKKoutrouli MTsetsos FMarenco SCasey CKinrot SMasse NYLee DTherrien KShao ZVoloudakis GHoffman GEWang XArgyriou SAlvia MRoussos PKatsel PPsychAD ConsortiumBendl JHong AFullard JFMathur DN M PBennett DABurstein DHaroutunian VGirdhar KPjanic MClarence TJensen LJFortes JMfalseSingle-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseases.Neurodegenerative and neuropsychiatric diseases impose a significant societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited. To gain deeper insights into the etiology of different brain diseases, we used specimens from 1,494 unique donors to generate a population-scale single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex (DLPFC), comprising over 6.3 million individual nuclei. The cohort includes neurotypical controls as well as donors affected by eight common and complex brain disorders: Alzheimer's disease (AD), diffuse Lewy body disease (DLBD), vascular dementia (Vas), Parkinson's disease (PD), tauopathy, frontotemporal dementia, schizophrenia, and bipolar disorder. We sh2024-01-01T00:00:00Z2024 Nov2026-06-16T03:17:15.118Z2026-06-16T03:09:41.94ZS-EPMC128339084160209810.1101/2024.10.31.24316513