biostudies-literatureZhou TNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNIDCR NIH HHSU.S. Department of DefenseNational Institute of Dental and Craniofacial ResearchNational Institutes of HealthUS Army Medical Research and Development CommandNIAMS NIH HHS123919https://www.ebi.ac.uk/biostudies/studies/S-EPMC12834038biostudies-literatureUnknown329Bone grafting remains one of the most common surgical procedures worldwide, with alloplastic grafts offering scalable and versatile alternatives to autografts. Biodegradable polyester-based scaffolds have emerged as a promising solution due to their tunable mechanical properties, biocompatibility, biodegradability, and recent advances in fabrication technologies. However, their lack of intrinsic bioactivity has driven increasing interest in bioactive functionalization. As a candidate for such functionalization, peptides offer several advantages, including ease of synthesis, specificity in biological interactions, and adaptability to chemical modification. This review provides a comprehensive overview of biodegradable polyester-peptide scaffold systems for bone tissue engineering. In particBiomaterialsPeptide-conjugated biodegradable polyester scaffolds for bone regeneration.PMC12834038R01DE027662W81XWH-20-1-0572R01AR075770R01 AR075770R01 DE027662Zhou TMa PXfalsePeptide-conjugated biodegradable polyester scaffolds for bone regeneration.Bone grafting remains one of the most common surgical procedures worldwide, with alloplastic grafts offering scalable and versatile alternatives to autografts. Biodegradable polyester-based scaffolds have emerged as a promising solution due to their tunable mechanical properties, biocompatibility, biodegradability, and recent advances in fabrication technologies. However, their lack of intrinsic bioactivity has driven increasing interest in bioactive functionalization. As a candidate for such functionalization, peptides offer several advantages, including ease of synthesis, specificity in biological interactions, and adaptability to chemical modification. This review provides a comprehensive overview of biodegradable polyester-peptide scaffold systems for bone tissue engineering. In partic2026-01-01T00:00:00Z2026 Jun2026-06-15T08:49:09.981Z2026-06-15T03:11:20.997ZS-EPMC128340384144303710.1016/j.biomaterials.2025.123919