{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Blumhagen RZ"],"funding":["NHLBI NIH HHS"],"pubmed_abstract":["We used spatial transcriptomics from idiopathic pulmonary fibrosis (IPF) and unaffected control lung tissue to further understand the pathogenesis of MUC5B-driven lung fibrosis. We captured 43 fields of view in 15 IPF and 13 controls with and without the <i>MUC5B</i> promoter variant using the CosMx<sup>®</sup> platform and identified 19 cell types via semi-supervised clustering. <i>MUC5B</i> was ectopically expressed in AT2 cells in controls with the risk variant. We observed a decreased proportion of AT2 cells in controls and an increased proportion of aberrant basaloid cells in IPF associated with the <i>MUC5B</i> risk variant. We identified co-localized expression of <i>MUC5B</i> in respiratory bronchioles with 13 genes including the endoplasmic reticulum (ER) stress marker <i>XBP1</i>"],"journal":["American journal of respiratory cell and molecular biology"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12834077"],"repository":["biostudies-literature"],"pubmed_title":["Ectopic Expression of &lt;i&gt;MUC5B&lt;/i&gt; in the Respiratory Bronchiole Initiates Endoplasmic Reticulum Stress in the IPF Lung."],"pmcid":["PMC12834077"],"funding_grant_id":["R01 HL158668","UH3 HL123442","P01 HL092870","R01 HL097163","UG3 HL151865","P01 HL162607"],"pubmed_authors":["Cool CD","Davidson EJ","Schwartz DA","Yang IV","Fingerlin TE","Blumhagen RZ","Kurche JS","Dobrinskikh E","Ma X","Huber JP","Heinz D"],"additional_accession":[]},"is_claimable":false,"name":"Ectopic Expression of &lt;i&gt;MUC5B&lt;/i&gt; in the Respiratory Bronchiole Initiates Endoplasmic Reticulum Stress in the IPF Lung.","description":"We used spatial transcriptomics from idiopathic pulmonary fibrosis (IPF) and unaffected control lung tissue to further understand the pathogenesis of MUC5B-driven lung fibrosis. We captured 43 fields of view in 15 IPF and 13 controls with and without the <i>MUC5B</i> promoter variant using the CosMx<sup>®</sup> platform and identified 19 cell types via semi-supervised clustering. <i>MUC5B</i> was ectopically expressed in AT2 cells in controls with the risk variant. We observed a decreased proportion of AT2 cells in controls and an increased proportion of aberrant basaloid cells in IPF associated with the <i>MUC5B</i> risk variant. We identified co-localized expression of <i>MUC5B</i> in respiratory bronchioles with 13 genes including the endoplasmic reticulum (ER) stress marker <i>XBP1</i>","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-13T05:26:44.643Z","creation":"2026-06-13T03:08:50.527Z"},"accession":"S-EPMC12834077","cross_references":{"pubmed":["41091081"],"doi":["10.1165/rcmb.2025-0261OC","10.1165/rcmb.2025-0261oc"]}}