{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Han Q"],"pubmed_abstract":["<h4>Background</h4>Polyunsaturated fatty acids (PUFAs), particularly ω-3 PUFAs, can improve sepsis prognosis. However, the relationship between the pre-infection levels of PUFAs and sepsis risk remains unclear.<h4>Methods</h4>We conducted a two-sample Mendelian randomization (MR) analysis using UK Biobank data to explore the causal association between circulating unsaturated fatty acids (UFAs) and sepsis susceptibility, complemented by a sepsis mouse model (cecal ligation and puncture, CLP) for validation.<h4>Results</h4>MR analysis revealed that ω-3 PUFAs (OR: 0.912, <i>p</i> = 0.005), ω-6 PUFAs (OR: 0.914, <i>p</i> = 0.036), total PUFAs (OR: 0.894, <i>p</i> = 0.003), and the PUFAs/MUFAs (monounsaturated fatty acids) ratio (OR: 0.927, <i>p</i> = 0.042) correlated with a reduced risk of se"],"journal":["Frontiers in medicine"],"pagination":["1701207"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12834780"],"repository":["biostudies-literature"],"pubmed_title":["Protective impact of circulating ω-3 PUFAs on sepsis susceptibility through <i>PCSK9</i> variant: evidence from Mendelian randomization and animal experiments."],"pmcid":["PMC12834780"],"pubmed_authors":["Han Q","He S","Li Z","Song Q"],"additional_accession":[]},"is_claimable":false,"name":"Protective impact of circulating ω-3 PUFAs on sepsis susceptibility through <i>PCSK9</i> variant: evidence from Mendelian randomization and animal experiments.","description":"<h4>Background</h4>Polyunsaturated fatty acids (PUFAs), particularly ω-3 PUFAs, can improve sepsis prognosis. However, the relationship between the pre-infection levels of PUFAs and sepsis risk remains unclear.<h4>Methods</h4>We conducted a two-sample Mendelian randomization (MR) analysis using UK Biobank data to explore the causal association between circulating unsaturated fatty acids (UFAs) and sepsis susceptibility, complemented by a sepsis mouse model (cecal ligation and puncture, CLP) for validation.<h4>Results</h4>MR analysis revealed that ω-3 PUFAs (OR: 0.912, <i>p</i> = 0.005), ω-6 PUFAs (OR: 0.914, <i>p</i> = 0.036), total PUFAs (OR: 0.894, <i>p</i> = 0.003), and the PUFAs/MUFAs (monounsaturated fatty acids) ratio (OR: 0.927, <i>p</i> = 0.042) correlated with a reduced risk of se","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-13T03:19:18.855Z","creation":"2026-06-13T03:09:20.358Z"},"accession":"S-EPMC12834780","cross_references":{"pubmed":["41608459"],"doi":["10.3389/fmed.2025.1701207"]}}