{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Torres G"],"funding":["Generalitat de Catalunya","Instituto de Salud Carlos III","Ministerio de Ciencia, Innovación y Universidades","Diputació de Lleida","ICREA Academia programme","irblleida “Grants for Research Staff in Training” (11th Edition, Modality E) of the IREP Program “amb la col·laboració de: Diputació de Lleida”"],"pagination":["3428"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12835136"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Advanced glycation end-products (AGEs) activate specific receptors (RAGE) promoting inflammation and oxidative stress. The lungs, with high RAGE expression, may be particularly susceptible to AGE-related injury. This study assessed whether baseline skin AGE levels, measured by skin autofluorescence (SAF), predict pulmonary function decline in middle-aged adults with cardiovascular risk factors. This ancillary analysis of the ILERVAS cohort included adults aged 45-70 years with cardiovascular risk factors but without diabetes or chronic kidney disease. Baseline data included demographics, lifestyle, and fasting blood tests. SAF was measured using AGE Reader™, and spirometry performed at baseline and after a median follow-up of 4 years. Associations between baseline SAF and annual declines i"],"journal":["Scientific reports"],"pubmed_title":["Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort."],"pmcid":["PMC12835136"],"funding_grant_id":["IJC2018-037792-I; PID2023-152233OB-I00","CP23/00095 (Miguel Servet 2023)","FI23/00253","AGAUR - 2021SGR00990","PI23/00237"],"pubmed_authors":["Castelblanco E","Franch-Nadal J","Torres G","Henriquez-Beltran M","de Batlle J","Barbe F","Pamplona R","Ortega M","Portero-Otin M","Godoy P","Lecube A","Simo R","Jove M","Hernandez C","Castro-Boque E","Royo M","Hernandez M","Fernandez E","Bermudez-Lopez M","Miquel E","Rius F","Martinez-Alonso M","Mauricio D","Gonzalez J","Targa ADS","Valdivielso JM","Gracia-Lavedan E","ILERVAS team"],"additional_accession":[]},"is_claimable":false,"name":"Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort.","description":"Advanced glycation end-products (AGEs) activate specific receptors (RAGE) promoting inflammation and oxidative stress. The lungs, with high RAGE expression, may be particularly susceptible to AGE-related injury. This study assessed whether baseline skin AGE levels, measured by skin autofluorescence (SAF), predict pulmonary function decline in middle-aged adults with cardiovascular risk factors. This ancillary analysis of the ILERVAS cohort included adults aged 45-70 years with cardiovascular risk factors but without diabetes or chronic kidney disease. Baseline data included demographics, lifestyle, and fasting blood tests. SAF was measured using AGE Reader™, and spirometry performed at baseline and after a median follow-up of 4 years. Associations between baseline SAF and annual declines i","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-16T03:08:43.857Z","creation":"2026-06-16T03:06:45.158Z"},"accession":"S-EPMC12835136","cross_references":{"pubmed":["41535697"],"doi":["10.1038/s41598-025-33414-8"]}}