biostudies-literatureTorres GGeneralitat de CatalunyaInstituto de Salud Carlos IIIMinisterio de Ciencia, Innovación y UniversidadesDiputació de LleidaICREA Academia programmeirblleida “Grants for Research Staff in Training” (11th Edition, Modality E) of the IREP Program “amb la col·laboració de: Diputació de Lleida”3428https://www.ebi.ac.uk/biostudies/studies/S-EPMC12835136biostudies-literatureUnknown16(1)Advanced glycation end-products (AGEs) activate specific receptors (RAGE) promoting inflammation and oxidative stress. The lungs, with high RAGE expression, may be particularly susceptible to AGE-related injury. This study assessed whether baseline skin AGE levels, measured by skin autofluorescence (SAF), predict pulmonary function decline in middle-aged adults with cardiovascular risk factors. This ancillary analysis of the ILERVAS cohort included adults aged 45-70 years with cardiovascular risk factors but without diabetes or chronic kidney disease. Baseline data included demographics, lifestyle, and fasting blood tests. SAF was measured using AGE Reader™, and spirometry performed at baseline and after a median follow-up of 4 years. Associations between baseline SAF and annual declines iScientific reportsSkin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort.PMC12835136IJC2018-037792-I; PID2023-152233OB-I00CP23/00095 (Miguel Servet 2023)FI23/00253AGAUR - 2021SGR00990PI23/00237Castelblanco EFranch-Nadal JTorres GHenriquez-Beltran Mde Batlle JBarbe FPamplona ROrtega MPortero-Otin MGodoy PLecube ASimo RJove MHernandez CCastro-Boque ERoyo MHernandez MFernandez EBermudez-Lopez MMiquel ERius FMartinez-Alonso MMauricio DGonzalez JTarga ADSValdivielso JMGracia-Lavedan EILERVAS teamfalseSkin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort.Advanced glycation end-products (AGEs) activate specific receptors (RAGE) promoting inflammation and oxidative stress. The lungs, with high RAGE expression, may be particularly susceptible to AGE-related injury. This study assessed whether baseline skin AGE levels, measured by skin autofluorescence (SAF), predict pulmonary function decline in middle-aged adults with cardiovascular risk factors. This ancillary analysis of the ILERVAS cohort included adults aged 45-70 years with cardiovascular risk factors but without diabetes or chronic kidney disease. Baseline data included demographics, lifestyle, and fasting blood tests. SAF was measured using AGE Reader™, and spirometry performed at baseline and after a median follow-up of 4 years. Associations between baseline SAF and annual declines i2026-01-01T00:00:00Z2026 Jan2026-06-16T03:08:43.857Z2026-06-16T03:06:45.158ZS-EPMC128351364153569710.1038/s41598-025-33414-8