biostudies-literatureUnknown13Zevallos-Morales A<h4>Background</h4>Peru has one of the highest burdens of asthma in the world, as well as large gaps in access to evidence-based treatments. Studies often overlook the ways in which the research context and data collection activities interact and influence the experience of a research participant, their perception of an intervention, and, by extension, study outcomes.<h4>Methods</h4>We conducted an individually randomized type 2 hybrid-implementation trial to evaluate the implementation and effectiveness of a locally adapted, multi-faceted intervention package to improve adherence to self-management practices. We enrolled 110 children with physician-diagnosed asthma living in nine urban districts Lima, Peru, and followed them monthly for 6 months. 101 children completed the study. ParticipFrontiers in public health1710746https://www.ebi.ac.uk/biostudies/studies/S-EPMC12835256biostudies-literatureEffectiveness and implementation of a multi-faceted intervention to facilitate adoption of asthma self-management practices in Peruvian children and adolescents: a hybrid type 2 individually randomized controlled trial.PMC12835256Zevallos-Morales AFlores-Flores OAnguera MTSiddharthan TPsoter KJReif DRomani-Huacani EUnderhill LJPollard SLPortell MfalseEffectiveness and implementation of a multi-faceted intervention to facilitate adoption of asthma self-management practices in Peruvian children and adolescents: a hybrid type 2 individually randomized controlled trial.<h4>Background</h4>Peru has one of the highest burdens of asthma in the world, as well as large gaps in access to evidence-based treatments. Studies often overlook the ways in which the research context and data collection activities interact and influence the experience of a research participant, their perception of an intervention, and, by extension, study outcomes.<h4>Methods</h4>We conducted an individually randomized type 2 hybrid-implementation trial to evaluate the implementation and effectiveness of a locally adapted, multi-faceted intervention package to improve adherence to self-management practices. We enrolled 110 children with physician-diagnosed asthma living in nine urban districts Lima, Peru, and followed them monthly for 6 months. 101 children completed the study. Particip2025-01-01T00:00:00Z20252026-06-15T08:53:38.686Z2026-06-15T03:11:55.504ZS-EPMC128352564160791510.3389/fpubh.2025.1710746