{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Murali KP"],"funding":["NIA NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","BrightFocus Foundation","American Academy of Sleep Medicine","Alzheimer&apos;s Association","Alzheimer's Association","National Institute on Aging"],"pagination":["e71144"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12835558"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>Obstructive sleep apnea (OSA) is associated with Alzheimer's disease (AD) risk. Racial-, ethnic-, and sex-specific mechanisms of OSA and AD risk were examined.<h4>Methods</h4>We analyzed data from 3978 polysomnography patients without cognitive decline aged ≥ 60 including 663 OSA+ patients (284 non-Hispanic White, 207 Black, 172 Hispanic) matched to OSA- cohorts (1:1, n = 663; 1:4, n = 2652) and followed for AD through 2013.<h4>Results</h4>During the 8.5 (standard deviation 1.4) year period, 358 patients developed AD. AD risk was higher for Black (adjusted hazard ratio [aHR] 2.24 [1.24-2.71]), Hispanic (aHR 1.73, [1.38-3.51]), White (aHR 1.83, [1.21-3.37]), male (aHR 2.38, [1.31-3.47]), and female (aHR 1.37, [1.14-2.41]) patients. Hypoxia, sleep fragmentation, and sleep "],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Racial, ethnic and sex-specific mechanisms of obstructive sleep apnea and Alzheimer's disease risk."],"pmcid":["PMC12835558"],"funding_grant_id":["RF1AG083975","24AARF-D-1243696","K23AG068534","R01HL157954","L30AG064670","BrightFocus-ADR-22-924755","24AARF‐D‐1243696","BrightFocus‐ADR‐22‐924755","AARG‐D‐21‐848397","P30AG066512","AASM-231-BS-20","R01AG082278","AASM‐231‐BS‐20","AARG-D-21-848397"],"pubmed_authors":["Ogedegbe O","Valkanova E","Ramos AR","Umasabor-Bubu OQ","Ayappa I","Bernard M","Brewster G","Williams N","Bubu OM","Briggs A","Turner A","Johnson DA","Mbah AK","Gills J","Udeh-Momoh CT","Osorio R","Jean-Louis G","Muller C","Murali KP","Osakwe Z"],"additional_accession":[]},"is_claimable":false,"name":"Racial, ethnic and sex-specific mechanisms of obstructive sleep apnea and Alzheimer's disease risk.","description":"<h4>Background</h4>Obstructive sleep apnea (OSA) is associated with Alzheimer's disease (AD) risk. Racial-, ethnic-, and sex-specific mechanisms of OSA and AD risk were examined.<h4>Methods</h4>We analyzed data from 3978 polysomnography patients without cognitive decline aged ≥ 60 including 663 OSA+ patients (284 non-Hispanic White, 207 Black, 172 Hispanic) matched to OSA- cohorts (1:1, n = 663; 1:4, n = 2652) and followed for AD through 2013.<h4>Results</h4>During the 8.5 (standard deviation 1.4) year period, 358 patients developed AD. AD risk was higher for Black (adjusted hazard ratio [aHR] 2.24 [1.24-2.71]), Hispanic (aHR 1.73, [1.38-3.51]), White (aHR 1.83, [1.21-3.37]), male (aHR 2.38, [1.31-3.47]), and female (aHR 1.37, [1.14-2.41]) patients. Hypoxia, sleep fragmentation, and sleep ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-14T05:58:29.234Z","creation":"2026-06-14T03:15:21.298Z"},"accession":"S-EPMC12835558","cross_references":{"pubmed":["41588822"],"doi":["10.1002/alz.71144"]}}