{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Signini EF"],"funding":["Funda ç ão de Amparo à Pesquisa do Estado de S ão Paulo (FAPESP)","Conselho Nacional de Desenvolvimento Cient ífico e Tecnol ógico (CNPq)","Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","Fundação de Amparo à Pesquisa do Estado de São Paulo","Coordena ç ão de Aperfei çoamento de Pessoal de N ível Superior (CAPES)"],"pagination":["e70739"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12835618"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["Cardiovascular autonomic modulation (CAM) and cardiorespiratory fitness (CRF) are well-established predictors of health. Identifying metabolites associated with integrated CAM-CRF profiles may help characterize healthy physiological states. This study aimed to investigate metabolic signatures representing distinct CAM-CRF profiles in apparently healthy individuals. Non-obese individuals (n = 127, 43 ± 14 years) underwent fasting blood collection for serum metabolome (SM) analysis, cardiovascular assessment, and a cardiopulmonary exercise test to access CAM and CRF. CAM-CRF profiles were obtained separately by sex using principal components analysis (PCA) of CAM and CRF. Subjects' scores from the first two principal components of the PCA were used to generate the groups. Groups' SM were com"],"journal":["Physiological reports"],"pubmed_title":["Metabolic signatures of the integrated profile of cardiovascular autonomic modulation and cardiorespiratory fitness in apparently healthy individuals."],"pmcid":["PMC12835618"],"funding_grant_id":["2023/01626-2","001","2023/09582-4","2023/09582‐4","2023/01626‐2","151218/2023‐4","151218/2023-4","2016/22215-7","2014/50244-6","2014/50244‐6","2016/22215‐7"],"pubmed_authors":["Rehder-Santos P","Ferreira AG","Oliveira RV","Signini EF","Porta A","Milan-Mattos JC","Carneiro RL","Catai AM","Castro A","de Oliveira JM"],"additional_accession":[]},"is_claimable":false,"name":"Metabolic signatures of the integrated profile of cardiovascular autonomic modulation and cardiorespiratory fitness in apparently healthy individuals.","description":"Cardiovascular autonomic modulation (CAM) and cardiorespiratory fitness (CRF) are well-established predictors of health. Identifying metabolites associated with integrated CAM-CRF profiles may help characterize healthy physiological states. This study aimed to investigate metabolic signatures representing distinct CAM-CRF profiles in apparently healthy individuals. Non-obese individuals (n = 127, 43 ± 14 years) underwent fasting blood collection for serum metabolome (SM) analysis, cardiovascular assessment, and a cardiopulmonary exercise test to access CAM and CRF. CAM-CRF profiles were obtained separately by sex using principal components analysis (PCA) of CAM and CRF. Subjects' scores from the first two principal components of the PCA were used to generate the groups. Groups' SM were com","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-09T06:56:13.077Z","creation":"2026-06-09T03:11:46.723Z"},"accession":"S-EPMC12835618","cross_references":{"pubmed":["41588850"],"doi":["10.14814/phy2.70739"]}}