{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hatano K"],"funding":["The 4th CST Education and Training Grant was provided by Japanese Society of Endourology and Robotics","Grants-in-Aid for Scientific Research KAKENHI was provided by Japan Society for the Promotion of Science"],"pagination":["e70267"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12835680"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(1)"],"pubmed_abstract":["<h4>Objectives</h4>Nerve-sparing techniques are commonly used in retroperitoneal lymph node dissection (RPLND) for patients with testicular cancer to preserve postoperative ejaculation. Laparoscopic RPLND is applicable to small residual masses; however, nerve-sparing techniques remain challenging. This study aimed to establish a safe, bilateral nerve-sparing laparoscopic RPLND via the transperitoneal approach. The technique was developed through cadaveric surgical training (CST) and applied clinically.<h4>Methods</h4>Thiel-fixed human cadavers were used for CST. In patients with testicular cancer after chemotherapy, laparoscopic RPLND was performed based on normalized tumor markers, typically with a residual mass of 5 cm or less. Patients were placed in the lateral position, and four to six ports were used, including the umbilical port; central ports were shared bilaterally. The dissection extent followed a bilateral full-template approach.<h4>Results</h4>In CST, lumbar splanchnic nerves were identified and preserved, supporting the clinical feasibility of laparoscopic RPLND. The bilateral nerve-sparing laparoscopic RPLND was performed in 10 patients: 6 with non-seminoma and 4 with seminoma. The mean pre-chemotherapy tumor diameter was 2.7 cm (range, 1.2-5.6 cm). The mean blood loss was 165 mL (range, 0-540 mL). The bilateral lumbar splanchnic nerves were preserved in all cases, and postoperative ejaculatory function was confirmed to be preserved in 9 cases. Surgical complications included Grade 1 chyle leakage in 5 patients, all of whom improved with conservative management.<h4>Conclusions</h4>A laparoscopic bilateral nerve-sparing RPLND technique was developed to achieve both minimal invasiveness and preservation of ejaculatory function. Long-term follow-up is necessary to confirm oncological outcomes."],"journal":["International journal of urology : official journal of the Japanese Urological Association"],"pubmed_title":["Laparoscopic Bilateral Nerve-Sparing Retroperitoneal Lymph Node Dissection for Testicular Cancer After Chemotherapy."],"pmcid":["PMC12835680"],"funding_grant_id":["25K02772"],"pubmed_authors":["Imamura R","Nonomura N","Mitsunari K","Fukuhara S","Kawamura M","Hayashi T","Nakazawa S","Kato T","Ueda N","Takezawa K","Kakuta Y","Ishizuya Y","Nakamura Y","Yamamoto Y","Kawashima A","Hatano K"],"additional_accession":[]},"is_claimable":false,"name":"Laparoscopic Bilateral Nerve-Sparing Retroperitoneal Lymph Node Dissection for Testicular Cancer After Chemotherapy.","description":"<h4>Objectives</h4>Nerve-sparing techniques are commonly used in retroperitoneal lymph node dissection (RPLND) for patients with testicular cancer to preserve postoperative ejaculation. Laparoscopic RPLND is applicable to small residual masses; however, nerve-sparing techniques remain challenging. This study aimed to establish a safe, bilateral nerve-sparing laparoscopic RPLND via the transperitoneal approach. The technique was developed through cadaveric surgical training (CST) and applied clinically.<h4>Methods</h4>Thiel-fixed human cadavers were used for CST. In patients with testicular cancer after chemotherapy, laparoscopic RPLND was performed based on normalized tumor markers, typically with a residual mass of 5 cm or less. Patients were placed in the lateral position, and four to six ports were used, including the umbilical port; central ports were shared bilaterally. The dissection extent followed a bilateral full-template approach.<h4>Results</h4>In CST, lumbar splanchnic nerves were identified and preserved, supporting the clinical feasibility of laparoscopic RPLND. The bilateral nerve-sparing laparoscopic RPLND was performed in 10 patients: 6 with non-seminoma and 4 with seminoma. The mean pre-chemotherapy tumor diameter was 2.7 cm (range, 1.2-5.6 cm). The mean blood loss was 165 mL (range, 0-540 mL). The bilateral lumbar splanchnic nerves were preserved in all cases, and postoperative ejaculatory function was confirmed to be preserved in 9 cases. Surgical complications included Grade 1 chyle leakage in 5 patients, all of whom improved with conservative management.<h4>Conclusions</h4>A laparoscopic bilateral nerve-sparing RPLND technique was developed to achieve both minimal invasiveness and preservation of ejaculatory function. Long-term follow-up is necessary to confirm oncological outcomes.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-16T07:09:17.402Z","creation":"2026-06-16T03:09:48.197Z"},"accession":"S-EPMC12835680","cross_references":{"pubmed":["41150616"],"doi":["10.1111/iju.70267"]}}