{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Layden RM"],"funding":["National Institute of Neurological Disorders and Stroke/National Institute on Aging","NINDS NIH HHS"],"pagination":["e71032"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12836376"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Introduction</h4>This studyexamined the independent contribution of chronic traumatic encephalopathy (CTE) neuropathology to symptoms.<h4>Methods</h4>The sample included 614 brain donors with (n = 366) and without (n = 248) autopsy-confirmed CTE. Brain donors with other major neurodegenerative disease diagnoses were excluded. Informants completed cognitive and neuropsychiatric measures. Dementia was determined during diagnostic consensus conferences.<h4>Results</h4>CTE stage IV (of IV) was associated with 4.48 (95% confidence interval [CI] = 1.97-10.90) increased odds of having dementia. CTE stage III had an odds ratio of 2.12 (95% CI = 1.91-3.77). Higher CTE stage was associated with greater informant-reported cognitive symptoms (p < 0.01). There were no associations with mood/behavio"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["CTE neuropathology alone is associated with dementia and cognitive symptoms."],"pmcid":["PMC12836376"],"funding_grant_id":["R01NS122854","R01NS139383","U54 NS115266"],"pubmed_authors":["Mez J","Nowinski CJ","Goldstein LE","Miner AE","Palmisano JN","Layden RM","Stern RA","Groh JR","Martin BM","Gil SG","Kidd A","Stein TD","McKee AC","Alosco ML","Cantu RC","Tripodis Y","Nosek SB","Daneshvar DH","Lenio S","Abdolmohammadi B","Dwyer BC","Katz DI"],"additional_accession":[]},"is_claimable":false,"name":"CTE neuropathology alone is associated with dementia and cognitive symptoms.","description":"<h4>Introduction</h4>This studyexamined the independent contribution of chronic traumatic encephalopathy (CTE) neuropathology to symptoms.<h4>Methods</h4>The sample included 614 brain donors with (n = 366) and without (n = 248) autopsy-confirmed CTE. Brain donors with other major neurodegenerative disease diagnoses were excluded. Informants completed cognitive and neuropsychiatric measures. Dementia was determined during diagnostic consensus conferences.<h4>Results</h4>CTE stage IV (of IV) was associated with 4.48 (95% confidence interval [CI] = 1.97-10.90) increased odds of having dementia. CTE stage III had an odds ratio of 2.12 (95% CI = 1.91-3.77). Higher CTE stage was associated with greater informant-reported cognitive symptoms (p < 0.01). There were no associations with mood/behavio","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-09T06:52:29.838Z","creation":"2026-06-09T03:12:06.328Z"},"accession":"S-EPMC12836376","cross_references":{"pubmed":["41589584"],"doi":["10.1002/alz.71032"]}}