biostudies-literatureLayden RMNational Institute of Neurological Disorders and Stroke/National Institute on AgingNINDS NIH HHSe71032https://www.ebi.ac.uk/biostudies/studies/S-EPMC12836376biostudies-literatureUnknown22(1)<h4>Introduction</h4>This studyexamined the independent contribution of chronic traumatic encephalopathy (CTE) neuropathology to symptoms.<h4>Methods</h4>The sample included 614 brain donors with (n = 366) and without (n = 248) autopsy-confirmed CTE. Brain donors with other major neurodegenerative disease diagnoses were excluded. Informants completed cognitive and neuropsychiatric measures. Dementia was determined during diagnostic consensus conferences.<h4>Results</h4>CTE stage IV (of IV) was associated with 4.48 (95% confidence interval [CI] = 1.97-10.90) increased odds of having dementia. CTE stage III had an odds ratio of 2.12 (95% CI = 1.91-3.77). Higher CTE stage was associated with greater informant-reported cognitive symptoms (p < 0.01). There were no associations with mood/behavioAlzheimer's & dementia : the journal of the Alzheimer's AssociationCTE neuropathology alone is associated with dementia and cognitive symptoms.PMC12836376R01NS122854R01NS139383U54 NS115266Mez JNowinski CJGoldstein LEMiner AEPalmisano JNLayden RMStern RAGroh JRMartin BMGil SGKidd AStein TDMcKee ACAlosco MLCantu RCTripodis YNosek SBDaneshvar DHLenio SAbdolmohammadi BDwyer BCKatz DIfalseCTE neuropathology alone is associated with dementia and cognitive symptoms.<h4>Introduction</h4>This studyexamined the independent contribution of chronic traumatic encephalopathy (CTE) neuropathology to symptoms.<h4>Methods</h4>The sample included 614 brain donors with (n = 366) and without (n = 248) autopsy-confirmed CTE. Brain donors with other major neurodegenerative disease diagnoses were excluded. Informants completed cognitive and neuropsychiatric measures. Dementia was determined during diagnostic consensus conferences.<h4>Results</h4>CTE stage IV (of IV) was associated with 4.48 (95% confidence interval [CI] = 1.97-10.90) increased odds of having dementia. CTE stage III had an odds ratio of 2.12 (95% CI = 1.91-3.77). Higher CTE stage was associated with greater informant-reported cognitive symptoms (p < 0.01). There were no associations with mood/behavio2026-01-01T00:00:00Z2026 Jan2026-06-09T06:52:29.838Z2026-06-09T03:12:06.328ZS-EPMC128363764158958410.1002/alz.71032