biostudies-literatureUnknown26(1)Tack C<h4>Background</h4>The role of low-grade-inflammation in Irritable Bowel Syndrome (IBS) a common disorder of gut-brain interaction is unclear. Association with symptom severity, as well as effects of first line treatments are understudied. In a large cohort of primary care IBS patients (DOMINO trial), a FODMAP-lowering diet application was superior in improving symptoms compared to standard medical therapy (otilonium bromide, OB). We investigated the level of pro-inflammatory markers in this IBS cohort and its changes by the DOMINO application and OB.<h4>Methods</h4>Inflammatory markers fecal calprotectin (FC), secretory IgA (sIgA), beta-defensin 2 (HBD-2), fecal elastase (Fel-1), and C-reactive protein (CRP) were analyzed at baseline and after 8-week of treatment (diet or medication). In BMC gastroenterology69https://www.ebi.ac.uk/biostudies/studies/S-EPMC12836962biostudies-literatureA study on the utility of inflammatory biomarkers in primary care irritable bowel syndrome: a sub analysis of the DOMINO randomized trial.PMC12836962Ceulemans SBesard LTack JTack CCapiau LRaat WVan Boxstael RGernay OPeetermans CGehesquiere BCarbone FVan den Houte KRaes JStubbe JVan Steenbergen SMaes SVandeput OfalseA study on the utility of inflammatory biomarkers in primary care irritable bowel syndrome: a sub analysis of the DOMINO randomized trial.<h4>Background</h4>The role of low-grade-inflammation in Irritable Bowel Syndrome (IBS) a common disorder of gut-brain interaction is unclear. Association with symptom severity, as well as effects of first line treatments are understudied. In a large cohort of primary care IBS patients (DOMINO trial), a FODMAP-lowering diet application was superior in improving symptoms compared to standard medical therapy (otilonium bromide, OB). We investigated the level of pro-inflammatory markers in this IBS cohort and its changes by the DOMINO application and OB.<h4>Methods</h4>Inflammatory markers fecal calprotectin (FC), secretory IgA (sIgA), beta-defensin 2 (HBD-2), fecal elastase (Fel-1), and C-reactive protein (CRP) were analyzed at baseline and after 8-week of treatment (diet or medication). In 2025-01-01T00:00:00Z2025 Dec2026-06-14T05:44:22.625Z2026-06-14T03:09:06.651ZS-EPMC128369624143694810.1186/s12876-025-04494-7