{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shinohara I"],"funding":["The Robert L. and Mary Ellenberg Chair in Surgery, Stanford University"],"pagination":["116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12837465"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["This study establishes a murine model of corticosteroid-associated osteonecrosis of the femoral head (ONFH) using a sustained-release prednisolone pellet and evaluates mitochondrial stress using <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and changes in key histologic markers of bone over a 6-week period. Sixteen 12-week-old Balb/C mice were divided into two groups: a prednisolone group (PRED) and a control group (SHAM). The PRED group received a subcutaneous 60-day sustained-release pellet containing 2.5 mg of prednisolone, while the SHAM group received placebo pellets. PET/CT imaging was performed at 1, 3, and 6 weeks. Bone mineral density (BMD) measurements, and histomorphological analyses for the number of empty lacunae, osteoblasts, oste"],"journal":["Bioengineering (Basel, Switzerland)"],"pubmed_title":["A Novel Murine Model to Study the Early Biological Events of Corticosteroid-Associated Osteonecrosis of the Femoral Head."],"pmcid":["PMC12837465"],"funding_grant_id":["NA"],"pubmed_authors":["Shinohara I","Susuki Y","Murayama M","Chow SK","Morita M","Cheung P","Uno T","Gao Q","Ma C","Beinat C","Goodman SB","Igei T","Moses AS"],"additional_accession":[]},"is_claimable":false,"name":"A Novel Murine Model to Study the Early Biological Events of Corticosteroid-Associated Osteonecrosis of the Femoral Head.","description":"This study establishes a murine model of corticosteroid-associated osteonecrosis of the femoral head (ONFH) using a sustained-release prednisolone pellet and evaluates mitochondrial stress using <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and changes in key histologic markers of bone over a 6-week period. Sixteen 12-week-old Balb/C mice were divided into two groups: a prednisolone group (PRED) and a control group (SHAM). The PRED group received a subcutaneous 60-day sustained-release pellet containing 2.5 mg of prednisolone, while the SHAM group received placebo pellets. PET/CT imaging was performed at 1, 3, and 6 weeks. Bone mineral density (BMD) measurements, and histomorphological analyses for the number of empty lacunae, osteoblasts, oste","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-13T03:25:59.675Z","creation":"2026-06-13T03:12:41.41Z"},"accession":"S-EPMC12837465","cross_references":{"pubmed":["41596047"],"doi":["10.3390/bioengineering13010116"]}}