{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dong L"],"funding":["National Natural Science Foundation of China"],"pagination":["311"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12837481"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(2)"],"pubmed_abstract":["Lipopolysaccharide (LPS) is widely used to model immune stress in weaned piglets, but it does not fully replicate the pathophysiological alterations induced by live bacterial infection. This study therefore established an oral <i>Salmonella enterica</i> (<i>SE</i>) challenge model and systematically compared its effects with those of LPS to evaluate its potential as a complementary immune stress paradigm. Forty piglets were assigned to five groups: control (saline), LPS (intraperitoneal, 100 μg/kg BW), and three SE groups receiving low-, middle-, or high-dose oral SE (1 × 10<sup>8</sup> CFU/mL, 2 × 10<sup>8</sup> CFU/mL, or 3 × 10<sup>8</sup> CFU/mL in a 10 mL saline volume, respectively). Both LPS and SE significantly reduced average daily gain, while only SE challenge decreased colon len"],"journal":["Animals : an open access journal from MDPI"],"pubmed_title":["<i>Salmonella enterica</i> as a Complementary Model to LPS for Immune Stress in Weaned Piglets: Systemic and Intestinal Alterations."],"pmcid":["PMC12837481"],"funding_grant_id":["32573262; 32302753"],"pubmed_authors":["Li W","Liu Z","Liu J","Yu L","Dong L","Wang H","Zhang C","Yuan H"],"additional_accession":[]},"is_claimable":false,"name":"<i>Salmonella enterica</i> as a Complementary Model to LPS for Immune Stress in Weaned Piglets: Systemic and Intestinal Alterations.","description":"Lipopolysaccharide (LPS) is widely used to model immune stress in weaned piglets, but it does not fully replicate the pathophysiological alterations induced by live bacterial infection. This study therefore established an oral <i>Salmonella enterica</i> (<i>SE</i>) challenge model and systematically compared its effects with those of LPS to evaluate its potential as a complementary immune stress paradigm. Forty piglets were assigned to five groups: control (saline), LPS (intraperitoneal, 100 μg/kg BW), and three SE groups receiving low-, middle-, or high-dose oral SE (1 × 10<sup>8</sup> CFU/mL, 2 × 10<sup>8</sup> CFU/mL, or 3 × 10<sup>8</sup> CFU/mL in a 10 mL saline volume, respectively). Both LPS and SE significantly reduced average daily gain, while only SE challenge decreased colon len","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-16T03:20:59.664Z","creation":"2026-06-16T03:10:12.303Z"},"accession":"S-EPMC12837481","cross_references":{"pubmed":["41594500"],"doi":["10.3390/ani16020311"]}}