{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(2)"],"submitter":["Goericke-Pesch S"],"pubmed_abstract":["Following the downregulation of testicular endocrine and germinative function by slow-release gonadotropin-releasing hormone (GnRH)-agonist implants, testicular functions are quickly restored after implant removal. As an intact blood-testis barrier (BTB) is crucial for normal spermatogenesis and its integrity is FSH- and androgen-dependent, alterations in the BTB gene and protein expressions during downregulation and subsequent restart seem inevitable. We investigated <i>occludin</i> (<i>OCLN</i>), <i>claudin</i> (<i>CLDN</i>) <i>3</i>, <i>5</i>, <i>11,</i> and <i>connexin</i> (<i>CX</i>) <i>43</i> mRNA-, and CLDN11 and CX43 protein expressions during GnRH implant-induced downregulation (W0) and restart of spermatogenesis after implant removal (week, W, 3-12). Untreated juvenile (JG) and a"],"journal":["Animals : an open access journal from MDPI"],"pagination":["254"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12837560"],"repository":["biostudies-literature"],"pubmed_title":["Testicular Gap (<i>CX43</i>) and Tight Junction (<i>OCLN</i>, <i>CLDN3</i>, <i>5</i> and <i>11</i>) Components in the Dog Are Affected by GnRH-Mediated Downregulation."],"pmcid":["PMC12837560"],"pubmed_authors":["Frimodt Ronnow A","Korber H","Wallrabenstein S","Langeheine M","Goericke-Pesch S","Packeiser EM","Fietz D","Rohrs L","Brehm R","Wehrend A","Hoffmann B"],"additional_accession":[]},"is_claimable":false,"name":"Testicular Gap (<i>CX43</i>) and Tight Junction (<i>OCLN</i>, <i>CLDN3</i>, <i>5</i> and <i>11</i>) Components in the Dog Are Affected by GnRH-Mediated Downregulation.","description":"Following the downregulation of testicular endocrine and germinative function by slow-release gonadotropin-releasing hormone (GnRH)-agonist implants, testicular functions are quickly restored after implant removal. As an intact blood-testis barrier (BTB) is crucial for normal spermatogenesis and its integrity is FSH- and androgen-dependent, alterations in the BTB gene and protein expressions during downregulation and subsequent restart seem inevitable. We investigated <i>occludin</i> (<i>OCLN</i>), <i>claudin</i> (<i>CLDN</i>) <i>3</i>, <i>5</i>, <i>11,</i> and <i>connexin</i> (<i>CX</i>) <i>43</i> mRNA-, and CLDN11 and CX43 protein expressions during GnRH implant-induced downregulation (W0) and restart of spermatogenesis after implant removal (week, W, 3-12). Untreated juvenile (JG) and a","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-12T03:16:56.931Z","creation":"2026-06-12T03:11:26.354Z"},"accession":"S-EPMC12837560","cross_references":{"pubmed":["41594443"],"doi":["10.3390/ani16020254"]}}