{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang X"],"funding":["Yuanping Wang","Xiao Wang"],"pagination":["40"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12837633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<b>Background:</b> In China, Carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) is dominated by sequence type 11 (ST11) harbouring KPC-2, with KL64 displacing KL47 and KL25 emerging. ST859 (ST11 variant) has caused outbreaks, but its epidemiology is unclear. <b>Materials and Methods:</b> A total of 99 non-duplicate CRKP isolates were collected from June to December 2024. Antimicrobial susceptibility was determined by broth microdilution. The genomic sequences of the strains were obtained using next-generation sequencing technology. Resistance genes, virulence loci, and plasmid replicons were identified with Kleborate, Abricate, and MOB-suite, respectively. <b>Results:</b> ST11 accounted for 63.64% and ST859 for 15.15%. All ST859 were KL19, while ST11 were mainly KL25 (60.32%) and KL6"],"journal":["Antibiotics (Basel, Switzerland)"],"pubmed_title":["Comparative Genomic and Resistance Analysis of ST859-KL19 and ST11 Carbapenem-Resistant <i>Klebsiella pneumoniae</i> with Diverse Capsular Serotypes."],"pmcid":["PMC12837633"],"funding_grant_id":["PWGw2025-05","PWRq2025-03"],"pubmed_authors":["Qiu Y","Feng J","Ren L","Zhao B","Zhang Y","Liang Y","Yang B","Wang X","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Comparative Genomic and Resistance Analysis of ST859-KL19 and ST11 Carbapenem-Resistant <i>Klebsiella pneumoniae</i> with Diverse Capsular Serotypes.","description":"<b>Background:</b> In China, Carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) is dominated by sequence type 11 (ST11) harbouring KPC-2, with KL64 displacing KL47 and KL25 emerging. ST859 (ST11 variant) has caused outbreaks, but its epidemiology is unclear. <b>Materials and Methods:</b> A total of 99 non-duplicate CRKP isolates were collected from June to December 2024. Antimicrobial susceptibility was determined by broth microdilution. The genomic sequences of the strains were obtained using next-generation sequencing technology. Resistance genes, virulence loci, and plasmid replicons were identified with Kleborate, Abricate, and MOB-suite, respectively. <b>Results:</b> ST11 accounted for 63.64% and ST859 for 15.15%. All ST859 were KL19, while ST11 were mainly KL25 (60.32%) and KL6","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-09T03:17:21.727Z","creation":"2026-06-09T03:11:56.293Z"},"accession":"S-EPMC12837633","cross_references":{"pubmed":["41594077"],"doi":["10.3390/antibiotics15010040"]}}