{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hurst SM"],"funding":["This pilot study was funded by private investors of Koru Biotech Solutions, and a project grand from New Zealand government agency Callaghan Innovation, Wellington, New Zealand."],"pagination":["310"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12837993"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(2)"],"pubmed_abstract":["Prevalence of LPS in Gram-negative bacterial udder infections determines mastitis severity and disease prognosis. This pilot study explores the notion that milk-soluble (s) LPS/IgG complex levels in dairy cows link mastitis severity to intramammary Gram-negative infections during early lactation. Milk, within a single herd, was analysed from (i) 34 early lactating cows with acute mastitis and (ii) milk selected from peak lactation cows displaying either healthy (SCC < 100 × 10<sup>3</sup> cells/mL, <i>n</i> = 146) or subclinical mastitis (SCC > 150 × 10<sup>3</sup> cells/mL, <i>n</i> = 135) characteristics. Milk was assessed for (i) sLPS/IgG using an \"in-house\" ELISA, (ii) udder inflammation using LDH activity, and (iii) bacterial presence applying on-farm and standard microbiological labo"],"journal":["Animals : an open access journal from MDPI"],"pubmed_title":["Pilot Study: Soluble LPS/IgG Milk Complexes in Relationship to Early Lactation Acute Mastitis in Dairy Cows."],"pmcid":["PMC12837993"],"funding_grant_id":["N/A"],"pubmed_authors":["Laven R","Hurst SM","Pernthaner A"],"additional_accession":[]},"is_claimable":false,"name":"Pilot Study: Soluble LPS/IgG Milk Complexes in Relationship to Early Lactation Acute Mastitis in Dairy Cows.","description":"Prevalence of LPS in Gram-negative bacterial udder infections determines mastitis severity and disease prognosis. This pilot study explores the notion that milk-soluble (s) LPS/IgG complex levels in dairy cows link mastitis severity to intramammary Gram-negative infections during early lactation. Milk, within a single herd, was analysed from (i) 34 early lactating cows with acute mastitis and (ii) milk selected from peak lactation cows displaying either healthy (SCC < 100 × 10<sup>3</sup> cells/mL, <i>n</i> = 146) or subclinical mastitis (SCC > 150 × 10<sup>3</sup> cells/mL, <i>n</i> = 135) characteristics. Milk was assessed for (i) sLPS/IgG using an \"in-house\" ELISA, (ii) udder inflammation using LDH activity, and (iii) bacterial presence applying on-farm and standard microbiological labo","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-13T03:23:39.763Z","creation":"2026-06-13T03:12:23.656Z"},"accession":"S-EPMC12837993","cross_references":{"pubmed":["41594498"],"doi":["10.3390/ani16020310"]}}