biostudies-literatureAnschuetz ATauRx Therapeutics Ltd Singapore28https://www.ebi.ac.uk/biostudies/studies/S-EPMC12838599biostudies-literatureUnknown16(1)The Icelandic mutation in the amyloid precursor protein (APP), APP^A673T, has been identified in Icelandic and Scandinavian populations and is associated with a significantly lower risk of developing Alzheimer's disease (AD). The introduction of the human APP^A673T form led to a reduction in amyloid β-protein (Aβ) production and tau pathology, but the effect of mouse APP^A673T on tau and Aβ pathology is not well studied. We have crossed line 66 (L66) tau transgenic mice that overexpress the P301S aggregation-prone form of tau with C57Bl6/J mice expressing a single-point mutation edited into the murine <i>APP</i> gene via CRISPR-Cas gene editing, known as mAPP^A673T. We have performed ELISA, histopathological, and behavioural analyses of heterozygous BiomoleculesEffect of the Icelandic Mutation APP^A673T in the Murine APP Gene on Phenotype of Line 66 Tau Mice.PMC12838599PAR1577 and PAR2074Anschuetz ARobinson LSchwab KMelis VPlatt BRiedel GMondesir MHarrington CRfalseEffect of the Icelandic Mutation APP^A673T in the Murine APP Gene on Phenotype of Line 66 Tau Mice.The Icelandic mutation in the amyloid precursor protein (APP), APP^A673T, has been identified in Icelandic and Scandinavian populations and is associated with a significantly lower risk of developing Alzheimer's disease (AD). The introduction of the human APP^A673T form led to a reduction in amyloid β-protein (Aβ) production and tau pathology, but the effect of mouse APP^A673T on tau and Aβ pathology is not well studied. We have crossed line 66 (L66) tau transgenic mice that overexpress the P301S aggregation-prone form of tau with C57Bl6/J mice expressing a single-point mutation edited into the murine <i>APP</i> gene via CRISPR-Cas gene editing, known as mAPP^A673T. We have performed ELISA, histopathological, and behavioural analyses of heterozygous 2025-01-01T00:00:00Z2025 Dec2026-06-11T03:16:43.019Z2026-06-11T03:12:17.221ZS-EPMC128385994159457010.3390/biom16010028