{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He Z"],"funding":["Tianjin Science and Technology Planning Project","Tianjin Aquatic Seed Industry Innovation Project"],"pagination":["108"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12839205"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Molting is a critical physiological process for the growth and development of <i>Eriocheir sinensis</i>. Any disruption in this process can significantly affect both survival rates and crab quality. The regulatory mechanisms of molting vary across different stages of the molting cycle and remain poorly understood. In this study, ATAC-seq and RNA-seq were combined to identify the integrated differentially expressed genes (IDEGs) in muscle across adjacent stages of the molting cycle. A total of 17, 491, 84, and 491 IDEGs were identified in the comparisons of inter-molt_vs_pre-molt, pre-molt_vs_molt, molt_vs_post-molt, and post-molt_vs_inter-molt stages, respectively. GO enrichment analysis of these IDEGs revealed several key signaling pathways involved in each adjacent molting stage. The GPC"],"journal":["Biomolecules"],"pubmed_title":["Integrated Analysis of ATAC-Seq and RNA-Seq Reveals the Signal Transduction Regulation of the Molting Cycle in the Muscle of Chinese Mitten Crab (<i>Eriocheir sinensis</i>)."],"pmcid":["PMC12839205"],"funding_grant_id":["24ZXZYSN00030","SCZYGG202402, YYLSFZ202502"],"pubmed_authors":["Li J","He Z","Zhang J","Wang B","Zhang R","Tan R","Sun J","Hao T"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Analysis of ATAC-Seq and RNA-Seq Reveals the Signal Transduction Regulation of the Molting Cycle in the Muscle of Chinese Mitten Crab (<i>Eriocheir sinensis</i>).","description":"Molting is a critical physiological process for the growth and development of <i>Eriocheir sinensis</i>. Any disruption in this process can significantly affect both survival rates and crab quality. The regulatory mechanisms of molting vary across different stages of the molting cycle and remain poorly understood. In this study, ATAC-seq and RNA-seq were combined to identify the integrated differentially expressed genes (IDEGs) in muscle across adjacent stages of the molting cycle. A total of 17, 491, 84, and 491 IDEGs were identified in the comparisons of inter-molt_vs_pre-molt, pre-molt_vs_molt, molt_vs_post-molt, and post-molt_vs_inter-molt stages, respectively. GO enrichment analysis of these IDEGs revealed several key signaling pathways involved in each adjacent molting stage. The GPC","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-17T03:21:19.68Z","creation":"2026-06-17T03:10:23.827Z"},"accession":"S-EPMC12839205","cross_references":{"pubmed":["41594647"],"doi":["10.3390/biom16010108"]}}