{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Victoria-Avila ZL"],"pubmed_abstract":["<b>Background:</b> Chronic inflammation and the development of cancer are closely linked, with components that comprise the tumour microenvironment-including proinflammatory cytokines-exerting essential tumourigenic effects. These proinflammatory cytokines include IL-1β, which has been reported to be overexpressed in several cancers and shown to activate several signalling pathways. These pathways may involve kinases such as AKT (serine/threonine kinase) and Src (Proto-oncogene tyrosine-protein kinase), and have a broad capacity to activate nuclear factors, including NF-κB (Nuclear Factor kappa-light-chain-enhancer of activated B cells), which can regulate the transcription of genes encoding proteins such as cIAP1 (Cellular Inhibitor of Apoptosis Protein 1), Bcl-2 (B-cell lymphoma 2), and "],"journal":["Biomedicines"],"pagination":["41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12839291"],"repository":["biostudies-literature"],"pubmed_title":["IL-1β Controls Proliferation, Apoptosis, and Necroptosis Through the PI3K/AKT/Src/NF-κB Pathway in Leukaemic Lymphoblasts."],"pmcid":["PMC12839291"],"pubmed_authors":["Lozada-Ruiz A","Lezama RA","Vela-Ojeda J","Dominguez-Lopez ML","Aleman OR","Victoria-Avila ZL","Reyes-Maldonado E"],"additional_accession":[]},"is_claimable":false,"name":"IL-1β Controls Proliferation, Apoptosis, and Necroptosis Through the PI3K/AKT/Src/NF-κB Pathway in Leukaemic Lymphoblasts.","description":"<b>Background:</b> Chronic inflammation and the development of cancer are closely linked, with components that comprise the tumour microenvironment-including proinflammatory cytokines-exerting essential tumourigenic effects. These proinflammatory cytokines include IL-1β, which has been reported to be overexpressed in several cancers and shown to activate several signalling pathways. These pathways may involve kinases such as AKT (serine/threonine kinase) and Src (Proto-oncogene tyrosine-protein kinase), and have a broad capacity to activate nuclear factors, including NF-κB (Nuclear Factor kappa-light-chain-enhancer of activated B cells), which can regulate the transcription of genes encoding proteins such as cIAP1 (Cellular Inhibitor of Apoptosis Protein 1), Bcl-2 (B-cell lymphoma 2), and ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-13T03:23:21.627Z","creation":"2026-06-13T03:12:21.65Z"},"accession":"S-EPMC12839291","cross_references":{"pubmed":["41595577"],"doi":["10.3390/biomedicines14010041"]}}