biostudies-literatureUnknown14(1)Victoria-Avila ZL<b>Background:</b> Chronic inflammation and the development of cancer are closely linked, with components that comprise the tumour microenvironment-including proinflammatory cytokines-exerting essential tumourigenic effects. These proinflammatory cytokines include IL-1β, which has been reported to be overexpressed in several cancers and shown to activate several signalling pathways. These pathways may involve kinases such as AKT (serine/threonine kinase) and Src (Proto-oncogene tyrosine-protein kinase), and have a broad capacity to activate nuclear factors, including NF-κB (Nuclear Factor kappa-light-chain-enhancer of activated B cells), which can regulate the transcription of genes encoding proteins such as cIAP1 (Cellular Inhibitor of Apoptosis Protein 1), Bcl-2 (B-cell lymphoma 2), and Biomedicines41https://www.ebi.ac.uk/biostudies/studies/S-EPMC12839291biostudies-literatureIL-1β Controls Proliferation, Apoptosis, and Necroptosis Through the PI3K/AKT/Src/NF-κB Pathway in Leukaemic Lymphoblasts.PMC12839291Lozada-Ruiz ALezama RAVela-Ojeda JDominguez-Lopez MLAleman ORVictoria-Avila ZLReyes-Maldonado EfalseIL-1β Controls Proliferation, Apoptosis, and Necroptosis Through the PI3K/AKT/Src/NF-κB Pathway in Leukaemic Lymphoblasts.<b>Background:</b> Chronic inflammation and the development of cancer are closely linked, with components that comprise the tumour microenvironment-including proinflammatory cytokines-exerting essential tumourigenic effects. These proinflammatory cytokines include IL-1β, which has been reported to be overexpressed in several cancers and shown to activate several signalling pathways. These pathways may involve kinases such as AKT (serine/threonine kinase) and Src (Proto-oncogene tyrosine-protein kinase), and have a broad capacity to activate nuclear factors, including NF-κB (Nuclear Factor kappa-light-chain-enhancer of activated B cells), which can regulate the transcription of genes encoding proteins such as cIAP1 (Cellular Inhibitor of Apoptosis Protein 1), Bcl-2 (B-cell lymphoma 2), and 2025-01-01T00:00:00Z2025 Dec2026-06-13T03:23:21.627Z2026-06-13T03:12:21.65ZS-EPMC128392914159557710.3390/biomedicines14010041