biostudies-literatureBan RSpecial Research Fund for Central Universities, Peking Union Medical CollegeChinese Academy of Medical Sciences Innovation Fund for Medical Sciences321https://www.ebi.ac.uk/biostudies/studies/S-EPMC12839809biostudies-literatureUnknown16(2)<b>Background/Objectives</b><b>:</b> Anti-mGluR1 encephalitis is a rare form of autoimmune encephalitis predominantly manifesting as acute/subacute cerebellar ataxia. We describe a newly diagnosed case series from our center and conduct a comprehensive review of reported cases worldwide to compare clinical manifestations, treatment options, and outcomes. <b>Methods:</b> We consecutively identified 11 patients at Peking Union Medical College Hospital, and additionally extracted clinical data from 42 previously published cases identified via PubMed and Google Scholar (search updated to 1 August 2025). Demographics, phenotypes, laboratory findings, imaging, treatment, and outcomes were systematically summarized. This pooled review was not prospectively registered, and extracted data from 21 pDiagnostics (Basel, Switzerland)Clinical Phenotypes and Prognosis of Anti-mGluR1 Encephalitis: A Single-Center Case Series and Comprehensive Literature Review.PMC1283980933320240072021-I2M-1-003Ren HJiang JLiu MGuan HShen DBan RFan SYu YfalseClinical Phenotypes and Prognosis of Anti-mGluR1 Encephalitis: A Single-Center Case Series and Comprehensive Literature Review.<b>Background/Objectives</b><b>:</b> Anti-mGluR1 encephalitis is a rare form of autoimmune encephalitis predominantly manifesting as acute/subacute cerebellar ataxia. We describe a newly diagnosed case series from our center and conduct a comprehensive review of reported cases worldwide to compare clinical manifestations, treatment options, and outcomes. <b>Methods:</b> We consecutively identified 11 patients at Peking Union Medical College Hospital, and additionally extracted clinical data from 42 previously published cases identified via PubMed and Google Scholar (search updated to 1 August 2025). Demographics, phenotypes, laboratory findings, imaging, treatment, and outcomes were systematically summarized. This pooled review was not prospectively registered, and extracted data from 21 p2026-01-01T00:00:00Z2026 Jan2026-06-09T03:20:41.758Z2026-06-09T03:12:02.388ZS-EPMC128398094159429610.3390/diagnostics16020321