{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(2)"],"submitter":["Yin K"],"pubmed_abstract":["<b>Background/Objectives:</b> Sex-specific differences in metabolic dysfunction-associated fatty liver disease (MAFLD)-related hepatocellular carcinoma (HCC) remain poorly understood. This study aimed to clarify sex-associated disparities in disease progression and recovery using a diethylnitrosamine (DEN) plus Western diet/fructose-induced murine model combined with artificial intelligence (AI)-assisted histological analysis. <b>Methods:</b> Male and female C57BL/6J mice received a single diethylnitrosamine injection and were fed a Western diet/fructose regimen for 38 weeks, followed by an 8-week recovery period on standard chow. Serum biochemical parameters were measured, and liver histology was assessed using second harmonic generation/two-photon excitation fluorescence (SHG/TPEF) micro"],"journal":["Diagnostics (Basel, Switzerland)"],"pagination":["234"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12840184"],"repository":["biostudies-literature"],"pubmed_title":["Use of Artificial Intelligence-Assisted Histopathology for Evaluation of Sex-Specific Progression and Regression of Hepatocellular Carcinoma Related to Metabolic Dysfunction-Associated Fatty Liver Disease."],"pmcid":["PMC12840184"],"pubmed_authors":["Wu N","Ren Y","Fei R","Akbary K","Cong X","Rao H","Liu B","Wang W","Yang Q","Teng X","Wang X","Wang Z","Liao M","Yin K","Liu F","Song Y","Ai X"],"additional_accession":[]},"is_claimable":false,"name":"Use of Artificial Intelligence-Assisted Histopathology for Evaluation of Sex-Specific Progression and Regression of Hepatocellular Carcinoma Related to Metabolic Dysfunction-Associated Fatty Liver Disease.","description":"<b>Background/Objectives:</b> Sex-specific differences in metabolic dysfunction-associated fatty liver disease (MAFLD)-related hepatocellular carcinoma (HCC) remain poorly understood. This study aimed to clarify sex-associated disparities in disease progression and recovery using a diethylnitrosamine (DEN) plus Western diet/fructose-induced murine model combined with artificial intelligence (AI)-assisted histological analysis. <b>Methods:</b> Male and female C57BL/6J mice received a single diethylnitrosamine injection and were fed a Western diet/fructose regimen for 38 weeks, followed by an 8-week recovery period on standard chow. Serum biochemical parameters were measured, and liver histology was assessed using second harmonic generation/two-photon excitation fluorescence (SHG/TPEF) micro","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-09T03:20:20.472Z","creation":"2026-06-09T03:12:01.071Z"},"accession":"S-EPMC12840184","cross_references":{"pubmed":["41594210"],"doi":["10.3390/diagnostics16020234"]}}