{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Capuano A"],"funding":["European Union","University of Salerno","european Union"],"pagination":["37"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12842763"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["Marine flora is a significant source of bioactive metabolites. These compounds have been demonstrated to have outstanding bioactivity and biocompatibility, enabling their use in various therapeutic applications. Therefore, examining the biological potential of marine natural compounds remains important, with particular emphasis on their interaction profiles to identify the macromolecular partners they can modulate. This study focused on the interactome profiling of the marine alkaloid caulerpin (CAU), isolated from the alga <i>Caulerpa cylindracea</i>. Along with the discovery of its antitumor properties, this metabolite has garnered attention for its potential therapeutic applications, including modulation of MAO-B and PPARs involved in inflammatory responses, as well as the discovery of "],"journal":["Marine drugs"],"pubmed_title":["Discovery of RUVBL1 as a Target of the Marine Alkaloid Caulerpin via MS-Based Functional Proteomics."],"pmcid":["PMC12842763"],"funding_grant_id":["PRIN PNRR 2022 \"P2022CKMPW","PNRR-MCNT2-2023-123777474","ORSA238540"],"pubmed_authors":["Gazzillo E","Lauro G","Brancaccio E","Capuano A","D'Urso G","Capasso L","Carbone M","Chini MG","Bifulco G","Casapullo A","Mollo E","Nebbioso A"],"additional_accession":[]},"is_claimable":false,"name":"Discovery of RUVBL1 as a Target of the Marine Alkaloid Caulerpin via MS-Based Functional Proteomics.","description":"Marine flora is a significant source of bioactive metabolites. These compounds have been demonstrated to have outstanding bioactivity and biocompatibility, enabling their use in various therapeutic applications. Therefore, examining the biological potential of marine natural compounds remains important, with particular emphasis on their interaction profiles to identify the macromolecular partners they can modulate. This study focused on the interactome profiling of the marine alkaloid caulerpin (CAU), isolated from the alga <i>Caulerpa cylindracea</i>. Along with the discovery of its antitumor properties, this metabolite has garnered attention for its potential therapeutic applications, including modulation of MAO-B and PPARs involved in inflammatory responses, as well as the discovery of ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-10T03:14:59.67Z","creation":"2026-06-10T03:11:15.84Z"},"accession":"S-EPMC12842763","cross_references":{"pubmed":["41590734"],"doi":["10.3390/md24010037"]}}