{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Goodwin AM"],"funding":["National Library of Medicine of the National Institutes of Health"],"pagination":["23"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12843166"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<b>Background/Objectives</b>: Psychological stress is a common problem but hard to universally treat. Personalized (N-of-1) trials assess a participant's response to multiple specific interventions. Though personalized (N-of-1) trials have been used in select interventions, no prior research has examined whether N-of-1 designs provide superior stress reduction relative to standard of care. <b>Methods</b>: Participants were randomized to personalized N-of-1 (N = 106) or standard-of-care (N = 106) arms for three stress-management interventions (mindfulness meditation; yoga; brisk walking). All participants completed ecological momentary assessments (EMA) of stress three times daily for 18 weeks (2-week baseline, 12-week intervention, 2-week assessment, and 2-week follow-up). After the interv"],"journal":["Journal of personalized medicine"],"pubmed_title":["Randomized Personalized Trial for Stress Management Compared to Standard of Care."],"pmcid":["PMC12843166"],"funding_grant_id":["R01LM012836"],"pubmed_authors":["Miller D","Perrin A","Cheung YK","Butler MJ","Goodwin AM","Chandereng T","Ahn H","Slotnick S","Davidson KW"],"additional_accession":[]},"is_claimable":false,"name":"Randomized Personalized Trial for Stress Management Compared to Standard of Care.","description":"<b>Background/Objectives</b>: Psychological stress is a common problem but hard to universally treat. Personalized (N-of-1) trials assess a participant's response to multiple specific interventions. Though personalized (N-of-1) trials have been used in select interventions, no prior research has examined whether N-of-1 designs provide superior stress reduction relative to standard of care. <b>Methods</b>: Participants were randomized to personalized N-of-1 (N = 106) or standard-of-care (N = 106) arms for three stress-management interventions (mindfulness meditation; yoga; brisk walking). All participants completed ecological momentary assessments (EMA) of stress three times daily for 18 weeks (2-week baseline, 12-week intervention, 2-week assessment, and 2-week follow-up). After the interv","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-09T03:19:39.148Z","creation":"2026-06-09T03:11:55.704Z"},"accession":"S-EPMC12843166","cross_references":{"pubmed":["41590516"],"doi":["10.3390/jpm16010023"]}}