biostudies-literatureGoodwin AMNational Library of Medicine of the National Institutes of Health23https://www.ebi.ac.uk/biostudies/studies/S-EPMC12843166biostudies-literatureUnknown16(1)<b>Background/Objectives</b>: Psychological stress is a common problem but hard to universally treat. Personalized (N-of-1) trials assess a participant's response to multiple specific interventions. Though personalized (N-of-1) trials have been used in select interventions, no prior research has examined whether N-of-1 designs provide superior stress reduction relative to standard of care. <b>Methods</b>: Participants were randomized to personalized N-of-1 (N = 106) or standard-of-care (N = 106) arms for three stress-management interventions (mindfulness meditation; yoga; brisk walking). All participants completed ecological momentary assessments (EMA) of stress three times daily for 18 weeks (2-week baseline, 12-week intervention, 2-week assessment, and 2-week follow-up). After the intervJournal of personalized medicineRandomized Personalized Trial for Stress Management Compared to Standard of Care.PMC12843166R01LM012836Miller DPerrin ACheung YKButler MJGoodwin AMChandereng TAhn HSlotnick SDavidson KWfalseRandomized Personalized Trial for Stress Management Compared to Standard of Care.<b>Background/Objectives</b>: Psychological stress is a common problem but hard to universally treat. Personalized (N-of-1) trials assess a participant's response to multiple specific interventions. Though personalized (N-of-1) trials have been used in select interventions, no prior research has examined whether N-of-1 designs provide superior stress reduction relative to standard of care. <b>Methods</b>: Participants were randomized to personalized N-of-1 (N = 106) or standard-of-care (N = 106) arms for three stress-management interventions (mindfulness meditation; yoga; brisk walking). All participants completed ecological momentary assessments (EMA) of stress three times daily for 18 weeks (2-week baseline, 12-week intervention, 2-week assessment, and 2-week follow-up). After the interv2026-01-01T00:00:00Z2026 Jan2026-06-09T03:19:39.148Z2026-06-09T03:11:55.704ZS-EPMC128431664159051610.3390/jpm16010023