{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Patel S"],"funding":["HSRD VA","US Department of Veterans Affairs"],"pagination":["467-479"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12844147"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["<h4>Background</h4>Chronic kidney disease (CKD) is defined by the KDIGO (Kidney Disease: Improving Global Outcomes) guideline as abnormal kidney structure or function, present for >3 months, with implications for health. KDIGO-defined CKD is associated with poor outcomes in patients with heart failure (HF). Less is known about whether these associations vary by left ventricular ejection fraction.<h4>Objectives</h4>This study aims to determine the prevalence and outcomes of KDIGO-defined CKD in heart failure with preserved ejection fraction (HFpEF), heart failure with mildly reduced ejection fraction (HFmrEF), and heart failure with reduced ejection fraction (HFrEF).<h4>Methods</h4>Of the 1,446,053 veterans with an HF diagnosis (1991-2017) in the national Veterans Affairs electronic health "],"journal":["JACC. Heart failure"],"pubmed_title":["Outcomes of KDIGO-Defined CKD in U.S. Veterans With HFpEF, HFmrEF, and HFrEF."],"pmcid":["PMC12844147"],"funding_grant_id":["SDR 02-237","I01 HX002422"],"pubmed_authors":["Fonarow GC","Heidenreich PA","Morgan CJ","Zeng-Treitler Q","Ahmed AA","Allman RM","Raman VK","Zhang S","Sheriff HM","Bakris G","Wu WC","Moore H","Anker SD","Deedwania P","Rangaswami J","Patel S","Butler J","Lam PH","Ahmed A","Faselis C"],"additional_accession":[]},"is_claimable":false,"name":"Outcomes of KDIGO-Defined CKD in U.S. Veterans With HFpEF, HFmrEF, and HFrEF.","description":"<h4>Background</h4>Chronic kidney disease (CKD) is defined by the KDIGO (Kidney Disease: Improving Global Outcomes) guideline as abnormal kidney structure or function, present for >3 months, with implications for health. KDIGO-defined CKD is associated with poor outcomes in patients with heart failure (HF). Less is known about whether these associations vary by left ventricular ejection fraction.<h4>Objectives</h4>This study aims to determine the prevalence and outcomes of KDIGO-defined CKD in heart failure with preserved ejection fraction (HFpEF), heart failure with mildly reduced ejection fraction (HFmrEF), and heart failure with reduced ejection fraction (HFrEF).<h4>Methods</h4>Of the 1,446,053 veterans with an HF diagnosis (1991-2017) in the national Veterans Affairs electronic health ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-07-16T23:23:56.647Z","creation":"2026-07-12T03:11:10.386Z"},"accession":"S-EPMC12844147","cross_references":{"pubmed":["39918536"],"doi":["10.1016/j.jchf.2024.11.007"]}}