biostudies-literaturePatel SHSRD VAUS Department of Veterans Affairs467-479https://www.ebi.ac.uk/biostudies/studies/S-EPMC12844147biostudies-literatureUnknown13(3)<h4>Background</h4>Chronic kidney disease (CKD) is defined by the KDIGO (Kidney Disease: Improving Global Outcomes) guideline as abnormal kidney structure or function, present for >3 months, with implications for health. KDIGO-defined CKD is associated with poor outcomes in patients with heart failure (HF). Less is known about whether these associations vary by left ventricular ejection fraction.<h4>Objectives</h4>This study aims to determine the prevalence and outcomes of KDIGO-defined CKD in heart failure with preserved ejection fraction (HFpEF), heart failure with mildly reduced ejection fraction (HFmrEF), and heart failure with reduced ejection fraction (HFrEF).<h4>Methods</h4>Of the 1,446,053 veterans with an HF diagnosis (1991-2017) in the national Veterans Affairs electronic health JACC. Heart failureOutcomes of KDIGO-Defined CKD in U.S. Veterans With HFpEF, HFmrEF, and HFrEF.PMC12844147SDR 02-237I01 HX002422Fonarow GCHeidenreich PAMorgan CJZeng-Treitler QAhmed AAAllman RMRaman VKZhang SSheriff HMBakris GWu WCMoore HAnker SDDeedwania PRangaswami JPatel SButler JLam PHAhmed AFaselis CfalseOutcomes of KDIGO-Defined CKD in U.S. Veterans With HFpEF, HFmrEF, and HFrEF.<h4>Background</h4>Chronic kidney disease (CKD) is defined by the KDIGO (Kidney Disease: Improving Global Outcomes) guideline as abnormal kidney structure or function, present for >3 months, with implications for health. KDIGO-defined CKD is associated with poor outcomes in patients with heart failure (HF). Less is known about whether these associations vary by left ventricular ejection fraction.<h4>Objectives</h4>This study aims to determine the prevalence and outcomes of KDIGO-defined CKD in heart failure with preserved ejection fraction (HFpEF), heart failure with mildly reduced ejection fraction (HFmrEF), and heart failure with reduced ejection fraction (HFrEF).<h4>Methods</h4>Of the 1,446,053 veterans with an HF diagnosis (1991-2017) in the national Veterans Affairs electronic health 2025-01-01T00:00:00Z2025 Mar2026-07-16T23:23:56.647Z2026-07-12T03:11:10.386ZS-EPMC128441473991853610.1016/j.jchf.2024.11.007