{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brito JM"],"funding":["Fundação de Apoio a Pesquisa do Estado de Goiás","Coordenação de Aperfeicoamento de Pessoal de Nível Superior","Universidade Federal de Mato Grosso do Sul","National Council for Scientific and Technological Development"],"pagination":["391"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12844472"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(2)"],"pubmed_abstract":["Herein, we disclose a highly efficient pathway toward 3-selenylated chromone derivatives via electrosynthesis domino C(sp<sup>2</sup>)-H bond selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, a wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amenable to scaling up the reaction. Additionally, the preliminary experiments revealed that this reaction probably proceeded via a cation pathway instead of a radical pathway."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Electrochemical Synthesis of 3-Selenyl-Chromones via Domino C(sp<sup>2</sup>)-H Bond Selenylation/Annulation of Enaminones."],"pmcid":["PMC12844472"],"funding_grant_id":["309975/2022-0","001","Chamada Pública FAPEG N° 21/2025 (PEE2025331000108).","404172/2023-7","401355/2025-0","Chamada Pública FAPEG N° 05/2025 (PVE2025041000055)","Chamada Pública FAPEG N° 21/2025 (PEE2025331000083)","405655/2023-1","316687/2023-5","Chamada Pública FAPEG/SES N° 18/2025 (ARB2025191000003)"],"pubmed_authors":["Singh VP","Camara GA","Frizon TEA","Saba S","Botteselle GV","Stein AL","Rafique J","Schneider AR","Casagrande GA","Oliveira IME","Braga AL","Moraes CAO","Brito JM"],"additional_accession":[]},"is_claimable":false,"name":"Electrochemical Synthesis of 3-Selenyl-Chromones via Domino C(sp<sup>2</sup>)-H Bond Selenylation/Annulation of Enaminones.","description":"Herein, we disclose a highly efficient pathway toward 3-selenylated chromone derivatives via electrosynthesis domino C(sp<sup>2</sup>)-H bond selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, a wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amenable to scaling up the reaction. Additionally, the preliminary experiments revealed that this reaction probably proceeded via a cation pathway instead of a radical pathway.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-09T03:18:44.832Z","creation":"2026-06-09T03:11:47.054Z"},"accession":"S-EPMC12844472","cross_references":{"pubmed":["41599438"],"doi":["10.3390/molecules31020391"]}}