biostudies-literatureBrito JMFundação de Apoio a Pesquisa do Estado de GoiásCoordenação de Aperfeicoamento de Pessoal de Nível SuperiorUniversidade Federal de Mato Grosso do SulNational Council for Scientific and Technological Development391https://www.ebi.ac.uk/biostudies/studies/S-EPMC12844472biostudies-literatureUnknown31(2)Herein, we disclose a highly efficient pathway toward 3-selenylated chromone derivatives via electrosynthesis domino C(sp²)-H bond selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, a wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amenable to scaling up the reaction. Additionally, the preliminary experiments revealed that this reaction probably proceeded via a cation pathway instead of a radical pathway.Molecules (Basel, Switzerland)Electrochemical Synthesis of 3-Selenyl-Chromones via Domino C(sp²)-H Bond Selenylation/Annulation of Enaminones.PMC12844472309975/2022-0001Chamada Pública FAPEG N° 21/2025 (PEE2025331000108).404172/2023-7401355/2025-0Chamada Pública FAPEG N° 05/2025 (PVE2025041000055)Chamada Pública FAPEG N° 21/2025 (PEE2025331000083)405655/2023-1316687/2023-5Chamada Pública FAPEG/SES N° 18/2025 (ARB2025191000003)Singh VPCamara GAFrizon TEASaba SBotteselle GVStein ALRafique JSchneider ARCasagrande GAOliveira IMEBraga ALMoraes CAOBrito JMfalseElectrochemical Synthesis of 3-Selenyl-Chromones via Domino C(sp²)-H Bond Selenylation/Annulation of Enaminones.Herein, we disclose a highly efficient pathway toward 3-selenylated chromone derivatives via electrosynthesis domino C(sp²)-H bond selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, a wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amenable to scaling up the reaction. Additionally, the preliminary experiments revealed that this reaction probably proceeded via a cation pathway instead of a radical pathway.2026-01-01T00:00:00Z2026 Jan2026-06-09T03:18:44.832Z2026-06-09T03:11:47.054ZS-EPMC128444724159943810.3390/molecules31020391