{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nalesnik M"],"funding":["National Institute of Environmental Health Sciences","NCATS NIH HHS","NIEHS NIH HHS","NCI NIH HHS"],"pagination":["kfaf150"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12844565"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["209(1)"],"pubmed_abstract":["Wildfires have surged in frequency and severity, and in 2022, they contributed to nearly 30% of the fine inhalable particulate matter (PM2.5) in the United States. Health effects from wildfire-induced wood smoke (WS) exposure include worsened pre-existing lung diseases and lung function, increased emergency room visits, and increased risk of premature death. Evidence suggests that males and females have unique responses to air pollutants, but sex-specific responses to WS remain understudied. To evaluate whether males and females differentially respond to WS, we analyzed induced sputum samples in humans following a controlled chamber exposure to WS. A total of 79 participants were exposed to 500 µg/m3 of WS for 2 h with intermittent exercise, and a subset of participants' samples were analy"],"journal":["Toxicological sciences : an official journal of the Society of Toxicology"],"pubmed_title":["Exploratory analysis of the impact of sex on sputum proteomic response to inhaled wood smoke in humans."],"pmcid":["PMC12844565"],"funding_grant_id":["K01 ES032837","UM1 TR004406","K01ES032837","P30 CA016086","T32 ES007126","R01 ES025124","T32ES007126","R01ES025124"],"pubmed_authors":["Hickman E","Mills AC","Jaspers I","Rager JE","Payton A","Nalesnik M","Mordant AL","Alexis NE","Rebuli ME","Almond M","Herring L","Peden DB"],"additional_accession":[]},"is_claimable":false,"name":"Exploratory analysis of the impact of sex on sputum proteomic response to inhaled wood smoke in humans.","description":"Wildfires have surged in frequency and severity, and in 2022, they contributed to nearly 30% of the fine inhalable particulate matter (PM2.5) in the United States. Health effects from wildfire-induced wood smoke (WS) exposure include worsened pre-existing lung diseases and lung function, increased emergency room visits, and increased risk of premature death. Evidence suggests that males and females have unique responses to air pollutants, but sex-specific responses to WS remain understudied. To evaluate whether males and females differentially respond to WS, we analyzed induced sputum samples in humans following a controlled chamber exposure to WS. A total of 79 participants were exposed to 500 µg/m3 of WS for 2 h with intermittent exercise, and a subset of participants' samples were analy","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-14T21:28:46.042Z","creation":"2026-06-25T03:07:33.356Z"},"accession":"S-EPMC12844565","cross_references":{"pubmed":["41134656"],"doi":["10.1093/toxsci/kfaf150"]}}