{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Carini V"],"funding":["Liverpool John Moores University"],"pagination":["13"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12845076"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["<b>Background/Objectives:</b> The growing threat posed by antimicrobial resistance to worldwide public health highlights the urgent need not only for new anti-infective candidates, but also for innovative formulation strategies capable of mediating effective delivery of anti-infective compounds. The current study, therefore, aimed to demonstrate the feasibility of formulating lipid-polymer hybrid nanoparticles (LPHNPs) with dual loading of both core and shell compartments for combination anti-infective delivery. <b>Methods:</b> LPHNPs containing the antibiotic cefotaxime within a chitosan polymer core and the novel antimicrobial peptide RN7IN6 within a bacteria-mimicking lipid shell were produced by microfluidic mixing, and optimized with respect to parameters including total flow rate, fl"],"journal":["Pharmaceutics"],"pubmed_title":["Dual Core-Shell Loaded Lipid-Polymer Hybrid Nanoparticles as Combination Anti-Infective Delivery Platforms."],"pmcid":["PMC12845076"],"funding_grant_id":["SCS ECR PhD Studentship"],"pubmed_authors":["Scagnetti G","Saleem I","Foulkes J","Evans K","Carini V","Gordon S"],"additional_accession":[]},"is_claimable":false,"name":"Dual Core-Shell Loaded Lipid-Polymer Hybrid Nanoparticles as Combination Anti-Infective Delivery Platforms.","description":"<b>Background/Objectives:</b> The growing threat posed by antimicrobial resistance to worldwide public health highlights the urgent need not only for new anti-infective candidates, but also for innovative formulation strategies capable of mediating effective delivery of anti-infective compounds. The current study, therefore, aimed to demonstrate the feasibility of formulating lipid-polymer hybrid nanoparticles (LPHNPs) with dual loading of both core and shell compartments for combination anti-infective delivery. <b>Methods:</b> LPHNPs containing the antibiotic cefotaxime within a chitosan polymer core and the novel antimicrobial peptide RN7IN6 within a bacteria-mimicking lipid shell were produced by microfluidic mixing, and optimized with respect to parameters including total flow rate, fl","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-15T03:12:15.905Z","creation":"2026-06-15T03:08:38.196Z"},"accession":"S-EPMC12845076","cross_references":{"pubmed":["41599120"],"doi":["10.3390/pharmaceutics18010013"]}}