biostudies-literatureMarzoli FNational Recovery and Resilience Plan (NRRP), 517 Mission 4, Component 2, Investment 1.1, Call for tender No. 104 published on 2.2.2022 518 by the Italian Ministry of University and Research (MUR), funded by the European Un- 519 ion -- NextGenerationEU --25https://www.ebi.ac.uk/biostudies/studies/S-EPMC12845790biostudies-literatureUnknown14(1)<b>Background</b>: People with multiple sclerosis (PwMS) face a wide range of social barriers, including stigma, limited support, and inaccessible environments, that restrict participation in physical activity (PA). Although PA is known to improve physical and psychological outcomes, its role in reducing social barriers has not been clearly synthesized. <b>Methods</b>: Following PRISMA 2020 guidelines, we conducted a systematic search of PubMed, Scopus, and Web of Science (January 1997-October 2025). Qualitative, quantitative, and mixed-methods studies examining how PA relates to social barriers, facilitators, or social outcomes for PwMS were included. Data were synthesized using a thematic analysis approach due to heterogeneity in study designs and outcomes. Risk of bias was assessed usinSports (Basel, Switzerland)Physical Activity as a Tool for Social Inclusion in Multiple Sclerosis: A Systematic Review of Qualitative, Quantitative, and Mixed-Methods Evidence.PMC128457901060 adopted on 17/07/2023 by the Italian Ministry of Ministry of University and ResearchDi Pinto GVelardi ACurzi DFerrari DMarcelli LColombo ASilvestri FGuidetti LMarzoli FDe Giorgio ACampanella MCardinali LfalsePhysical Activity as a Tool for Social Inclusion in Multiple Sclerosis: A Systematic Review of Qualitative, Quantitative, and Mixed-Methods Evidence.<b>Background</b>: People with multiple sclerosis (PwMS) face a wide range of social barriers, including stigma, limited support, and inaccessible environments, that restrict participation in physical activity (PA). Although PA is known to improve physical and psychological outcomes, its role in reducing social barriers has not been clearly synthesized. <b>Methods</b>: Following PRISMA 2020 guidelines, we conducted a systematic search of PubMed, Scopus, and Web of Science (January 1997-October 2025). Qualitative, quantitative, and mixed-methods studies examining how PA relates to social barriers, facilitators, or social outcomes for PwMS were included. Data were synthesized using a thematic analysis approach due to heterogeneity in study designs and outcomes. Risk of bias was assessed usin2026-01-01T00:00:00Z2026 Jan2026-06-15T03:14:36.869Z2026-06-15T03:08:56.826ZS-EPMC128457904159096710.3390/sports14010025