{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Donoso A"],"funding":["Instituto de Salud Carlos III"],"pagination":["101"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12846359"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["Circulating recombinant forms (CRFs) are important components of the HIV-1 pandemic. Previous studies have reported the propagation of diverse HIV-1 CRFs of South American origin in Europe. Here, through protease-reverse transcriptase (Pr-RT) and integrase sequence analyses, we identify a Spanish cluster (BC3) branching with a Brazilian virus (10BR_RJ009) previously classified as CRF146_BC. In Pr-RT, BC3 comprised 14 viruses and was nested within a larger cluster, comprising 22 Brazilian viruses and 1 Spanish virus branching outside of BC3. Near full-length genome analyses of five BC3 viruses revealed mosaic structures identical to 10BR_RJ009, with two breakpoints delimiting a ~0.3 kb subtype B fragment within an otherwise subtype C genome. Two other Brazilian viruses previously classified"],"journal":["Viruses"],"pubmed_title":["Viruses Previously Classified as CRF146_BC, a Circulating Recombinant Form of HIV-1 Recently Reported in Brazil, Represent Different Recombinant Forms, One of Which Is Circulating in Spain."],"pmcid":["PMC12846359"],"funding_grant_id":["PI19CIII/00042","PICIII16/00033","PI22CIII/00065"],"pubmed_authors":["Donoso A","Salicio Y","Cortizo S","Diez-Fuertes F","Baza-Caraciolo MB","Del Romero-Guerrero J","Zamarron P","Gomez-Gonzalez C","Canada-Garcia JE","Moreno-Lorenzo M","Miqueleiz A","Benito S","Delgado E","Iribarren JA","Thomson MM","Tellez R","Lorente-Sorolla C","Morano L"],"additional_accession":[]},"is_claimable":false,"name":"Viruses Previously Classified as CRF146_BC, a Circulating Recombinant Form of HIV-1 Recently Reported in Brazil, Represent Different Recombinant Forms, One of Which Is Circulating in Spain.","description":"Circulating recombinant forms (CRFs) are important components of the HIV-1 pandemic. Previous studies have reported the propagation of diverse HIV-1 CRFs of South American origin in Europe. Here, through protease-reverse transcriptase (Pr-RT) and integrase sequence analyses, we identify a Spanish cluster (BC3) branching with a Brazilian virus (10BR_RJ009) previously classified as CRF146_BC. In Pr-RT, BC3 comprised 14 viruses and was nested within a larger cluster, comprising 22 Brazilian viruses and 1 Spanish virus branching outside of BC3. Near full-length genome analyses of five BC3 viruses revealed mosaic structures identical to 10BR_RJ009, with two breakpoints delimiting a ~0.3 kb subtype B fragment within an otherwise subtype C genome. Two other Brazilian viruses previously classified","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-02T03:15:28.306Z","creation":"2026-07-02T03:08:29.713Z"},"accession":"S-EPMC12846359","cross_references":{"pubmed":["41600864"],"doi":["10.3390/v18010101"]}}