{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen X"],"funding":["Shuaichen","Hairui Fan"],"pagination":["11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12846478"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Porcine circovirus type 2 (PCV2), a widely distributed immunosuppressive virus, causes substantial economic losses in the global swine industry. <i>C1QTNF6</i> has emerged as a novel immunoregulatory factor attracting increasing research interest due to its dual roles in both pro-inflammatory and antiviral immune responses. However, the role of <i>C1QTNF6</i> in regulating PCV2 replication remains poorly characterized. Here, we analyzed <i>C1QTNF6</i> expression patterns and identified its highly specific expression in placental tissues in both humans and pigs. We then overexpressed <i>C1QTNF6</i> and conducted RNA sequencing analysis. Remarkably, 68 upregulated genes were identified, and most of them were interferon-stimulated genes (ISGs), including <i>MX2</i> and <i>ISG15</i>. Functiona"],"journal":["Veterinary sciences"],"pubmed_title":["The C1QTNF6-MX2 Antiviral Axis Inhibits Porcine Circovirus Type 2 Replication in Porcine Macrophages."],"pmcid":["PMC12846478"],"funding_grant_id":["BK20240921","24KJD230003"],"pubmed_authors":["Jiang J","Wu Z","Fan H","Bao X","Bao W","Xu C","Chen X","Wang H","Chen S"],"additional_accession":[]},"is_claimable":false,"name":"The C1QTNF6-MX2 Antiviral Axis Inhibits Porcine Circovirus Type 2 Replication in Porcine Macrophages.","description":"Porcine circovirus type 2 (PCV2), a widely distributed immunosuppressive virus, causes substantial economic losses in the global swine industry. <i>C1QTNF6</i> has emerged as a novel immunoregulatory factor attracting increasing research interest due to its dual roles in both pro-inflammatory and antiviral immune responses. However, the role of <i>C1QTNF6</i> in regulating PCV2 replication remains poorly characterized. Here, we analyzed <i>C1QTNF6</i> expression patterns and identified its highly specific expression in placental tissues in both humans and pigs. We then overexpressed <i>C1QTNF6</i> and conducted RNA sequencing analysis. Remarkably, 68 upregulated genes were identified, and most of them were interferon-stimulated genes (ISGs), including <i>MX2</i> and <i>ISG15</i>. Functiona","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-14T03:26:53.15Z","creation":"2026-06-14T03:16:34.899Z"},"accession":"S-EPMC12846478","cross_references":{"pubmed":["41600667"],"doi":["10.3390/vetsci13010011"]}}