{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Bian X"],"pubmed_abstract":["The remodeling of synapses in the hippocampus is intricately linked to processes of learning and memory. Research indicates that high-intensity interval training (HIIT) enhances cognitive functions reliant on the hippocampus in mice, although the specific receptor-mediated molecular pathways involved are not fully elucidated. Lactate, which is produced in significant amounts during HIIT, may function as a signaling agent in the brain through the lactate receptor G protein-coupled receptor 81 (GPR81), classified as a Gi-type G protein-coupled receptor. This investigation focused on the lactate/GPR81 pathway's contribution to synaptic remodeling in the hippocampus induced by HIIT and examined its downstream signaling characteristics. <i>In vivo</i> results demonstrated that HIIT led to an in"],"journal":["Frontiers in cell and developmental biology"],"pagination":["1699042"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12846946"],"repository":["biostudies-literature"],"pubmed_title":["HIIT-induced lactate/GPR81 signaling with dual branches converging on ERK1/2 contributes to hippocampal synaptic remodeling and memory improvement."],"pmcid":["PMC12846946"],"pubmed_authors":["Shang Q","Liu J","Wu M","Li J","Zhu L","Lou S","Bian X"],"additional_accession":[]},"is_claimable":false,"name":"HIIT-induced lactate/GPR81 signaling with dual branches converging on ERK1/2 contributes to hippocampal synaptic remodeling and memory improvement.","description":"The remodeling of synapses in the hippocampus is intricately linked to processes of learning and memory. Research indicates that high-intensity interval training (HIIT) enhances cognitive functions reliant on the hippocampus in mice, although the specific receptor-mediated molecular pathways involved are not fully elucidated. Lactate, which is produced in significant amounts during HIIT, may function as a signaling agent in the brain through the lactate receptor G protein-coupled receptor 81 (GPR81), classified as a Gi-type G protein-coupled receptor. This investigation focused on the lactate/GPR81 pathway's contribution to synaptic remodeling in the hippocampus induced by HIIT and examined its downstream signaling characteristics. <i>In vivo</i> results demonstrated that HIIT led to an in","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-06-15T04:48:49.873Z","creation":"2026-06-15T03:08:51.266Z"},"accession":"S-EPMC12846946","cross_references":{"pubmed":["41614058"],"doi":["10.3389/fcell.2026.1699042"]}}