biostudies-literatureUnknown17Jabbari-Zadeh FWarm autoimmune hemolytic anemia (wAIHA) is characterized by autoantibodies against proteins that comprise the Rh antigen system along with hemolysis. The presence of specific autoantibodies, especially autoantibodies with anti-e specificity, is rare. The pathophysiology, management, and outcomes in this condition, including with transfusion of e-antigen positive packed red blood cells (pRBCs), remain poorly understood. A 63-year-old woman presented with fatigue, jaundice, tea-colored urine, and dyspnea. She was diagnosed with wAIHA with anti-e specificity and developed worsening hemolysis after receiving a unit of e-antigen positive pRBCs with a drop in hemoglobin from 85 to 71 g/L. She achieved a complete response with a tapering course of prednisone and folate. We conducted a systematicTherapeutic advances in hematology20406207251410168https://www.ebi.ac.uk/biostudies/studies/S-EPMC12847652biostudies-literatureTransfusion-induced hemolysis in warm autoimmune hemolytic anemia with autoantibodies that have anti-e specificity: a case report and systematic review of the literature.PMC12847652Jabbari-Zadeh FSolh ZChin-Yee BGob AHoxha OHsia CCfalseTransfusion-induced hemolysis in warm autoimmune hemolytic anemia with autoantibodies that have anti-e specificity: a case report and systematic review of the literature.Warm autoimmune hemolytic anemia (wAIHA) is characterized by autoantibodies against proteins that comprise the Rh antigen system along with hemolysis. The presence of specific autoantibodies, especially autoantibodies with anti-e specificity, is rare. The pathophysiology, management, and outcomes in this condition, including with transfusion of e-antigen positive packed red blood cells (pRBCs), remain poorly understood. A 63-year-old woman presented with fatigue, jaundice, tea-colored urine, and dyspnea. She was diagnosed with wAIHA with anti-e specificity and developed worsening hemolysis after receiving a unit of e-antigen positive pRBCs with a drop in hemoglobin from 85 to 71 g/L. She achieved a complete response with a tapering course of prednisone and folate. We conducted a systematic2026-01-01T00:00:00Z20262026-06-11T05:34:01.073Z2026-06-11T03:08:15.468ZS-EPMC128476524161362510.1177/20406207251410168