biostudies-literatureUnknown25Jiang T<h4>Background</h4>The THBS gene family plays key functions in various diseases; however, its specific roles in colorectal cancer (CRC) have not been systematically characterized.<h4>Methods</h4>Multi-omics data and online databases were used to analyze the mRNA expression levels of the THBS gene family in CRC and their correlations with clinicopathological features and survival. This analysis identified THBS3 as a potential oncogene closely linked with CRC progression. Then, the relationship between THBS3 expression and the immune landscape was assessed. Single-cell RNA sequencing analyzed THBS3 distribution in CRC subtypes. Additionally, GO, KEGG, and GSEA enrichment analyses investigated the mechanisms of THBS3 in CRC. Molecular docking identified anticancer compounds with high affinityCancer informatics11769351251412614https://www.ebi.ac.uk/biostudies/studies/S-EPMC12847665biostudies-literatureTHBS3 Functions as a Novel Biomarker for Prognosis and Immunotherapeutic Response in Colorectal Cancer: An Integrative Analysis and Validation of the Thrombospondin Gene Family.PMC12847665Zhang NJiang TZhang LZou CSong HZhou HZhu SfalseTHBS3 Functions as a Novel Biomarker for Prognosis and Immunotherapeutic Response in Colorectal Cancer: An Integrative Analysis and Validation of the Thrombospondin Gene Family.<h4>Background</h4>The THBS gene family plays key functions in various diseases; however, its specific roles in colorectal cancer (CRC) have not been systematically characterized.<h4>Methods</h4>Multi-omics data and online databases were used to analyze the mRNA expression levels of the THBS gene family in CRC and their correlations with clinicopathological features and survival. This analysis identified THBS3 as a potential oncogene closely linked with CRC progression. Then, the relationship between THBS3 expression and the immune landscape was assessed. Single-cell RNA sequencing analyzed THBS3 distribution in CRC subtypes. Additionally, GO, KEGG, and GSEA enrichment analyses investigated the mechanisms of THBS3 in CRC. Molecular docking identified anticancer compounds with high affinity2026-01-01T00:00:00Z20262026-06-13T05:28:41.694Z2026-06-13T03:08:47.771ZS-EPMC128476654161341810.1177/11769351251412614