{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["36(2)"],"submitter":["Liao K"],"pubmed_abstract":["Methionine metabolism generates the substrate S-adenosylmethionine (SAM), which regulates epigenetic modifications crucial for various cellular processes, particularly tumorigenesis. However, whether methionine metabolism involves epigenetic mechanisms independent of SAM and what roles such mechanisms play in tumorigenesis remain unclear. We show here that the adenosylhomocysteinase (AHCY)-adenosine complex increases mRNA m<sup>6</sup>A levels in a non-global manner, promoting fatty acid synthesis and tumorigenesis. Adenosine increases mRNA m<sup>6</sup>A levels by binding to the methionine metabolism enzyme AHCY to form a complex, rather than depending on adenosine receptors. The AHCY-adenosine complex facilitates AHCY dimerization, with adenosine being crucial for dimer stability. AHCY d"],"journal":["Cell research"],"pagination":["152-172"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12848013"],"repository":["biostudies-literature"],"pubmed_title":["The AHCY-adenosine complex rewires mRNA methylation to enhance fatty acid biosynthesis and tumorigenesis."],"pmcid":["PMC12848013"],"pubmed_authors":["Wu QN","Xiao ZX","Wei C","Zeng ZL","Cao F","Hu HR","Sheng H","Zhao YX","Liao K","Feng ZQ","Xu RH","Qian ZY","Ju HQ","Li B","Pan WF","Lian SM","Mo HY"],"additional_accession":[]},"is_claimable":false,"name":"The AHCY-adenosine complex rewires mRNA methylation to enhance fatty acid biosynthesis and tumorigenesis.","description":"Methionine metabolism generates the substrate S-adenosylmethionine (SAM), which regulates epigenetic modifications crucial for various cellular processes, particularly tumorigenesis. However, whether methionine metabolism involves epigenetic mechanisms independent of SAM and what roles such mechanisms play in tumorigenesis remain unclear. We show here that the adenosylhomocysteinase (AHCY)-adenosine complex increases mRNA m<sup>6</sup>A levels in a non-global manner, promoting fatty acid synthesis and tumorigenesis. Adenosine increases mRNA m<sup>6</sup>A levels by binding to the methionine metabolism enzyme AHCY to form a complex, rather than depending on adenosine receptors. The AHCY-adenosine complex facilitates AHCY dimerization, with adenosine being crucial for dimer stability. AHCY d","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-16T03:11:25.653Z","creation":"2026-06-16T03:07:10.873Z"},"accession":"S-EPMC12848013","cross_references":{"pubmed":["41549122"],"doi":["10.1038/s41422-025-01213-5"]}}