{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(1)"],"submitter":["Ghazali R"],"pubmed_abstract":["The regiospecific ring expansion of 2<i>H</i>-azetines into halogenated pyrroles is disclosed. Simple reaction sequences have been developed to conceptualize this 4 → 5 skeletal editing strategy, taking advantage of the inherent reactivity of double bonds present in the initial four-membered ring systems. Detailed density functional theory (DFT) calculations are presented to explain this unusual rearrangement. Such a reaction design allows for the preparation of highly substituted halogenated pyrrole derivatives."],"journal":["JACS Au"],"pagination":["415-422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12848677"],"repository":["biostudies-literature"],"pubmed_title":["Regiospecific Skeletal Editing of Azetines toward Halogenated Pyrroles."],"pmcid":["PMC12848677"],"pubmed_authors":["Didier D","Immel S","Schick E","Ghazali R","Kranich J","Lepre S"],"additional_accession":[]},"is_claimable":false,"name":"Regiospecific Skeletal Editing of Azetines toward Halogenated Pyrroles.","description":"The regiospecific ring expansion of 2<i>H</i>-azetines into halogenated pyrroles is disclosed. Simple reaction sequences have been developed to conceptualize this 4 → 5 skeletal editing strategy, taking advantage of the inherent reactivity of double bonds present in the initial four-membered ring systems. Detailed density functional theory (DFT) calculations are presented to explain this unusual rearrangement. Such a reaction design allows for the preparation of highly substituted halogenated pyrrole derivatives.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-13T06:28:50.878Z","creation":"2026-06-13T03:12:40.919Z"},"accession":"S-EPMC12848677","cross_references":{"pubmed":["41614157"],"doi":["10.1021/jacsau.5c01324"]}}