biostudies-literatureUnknown6(1)Ghazali RThe regiospecific ring expansion of 2<i>H</i>-azetines into halogenated pyrroles is disclosed. Simple reaction sequences have been developed to conceptualize this 4 → 5 skeletal editing strategy, taking advantage of the inherent reactivity of double bonds present in the initial four-membered ring systems. Detailed density functional theory (DFT) calculations are presented to explain this unusual rearrangement. Such a reaction design allows for the preparation of highly substituted halogenated pyrrole derivatives.JACS Au415-422https://www.ebi.ac.uk/biostudies/studies/S-EPMC12848677biostudies-literatureRegiospecific Skeletal Editing of Azetines toward Halogenated Pyrroles.PMC12848677Didier DImmel SSchick EGhazali RKranich JLepre SfalseRegiospecific Skeletal Editing of Azetines toward Halogenated Pyrroles.The regiospecific ring expansion of 2<i>H</i>-azetines into halogenated pyrroles is disclosed. Simple reaction sequences have been developed to conceptualize this 4 → 5 skeletal editing strategy, taking advantage of the inherent reactivity of double bonds present in the initial four-membered ring systems. Detailed density functional theory (DFT) calculations are presented to explain this unusual rearrangement. Such a reaction design allows for the preparation of highly substituted halogenated pyrrole derivatives.2026-01-01T00:00:00Z2026 Jan2026-06-13T06:28:50.878Z2026-06-13T03:12:40.919ZS-EPMC128486774161415710.1021/jacsau.5c01324