{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou X"],"funding":["American Liver Foundation","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","National Natural Science Foundation of China","National Institutes of Health","NIH HHS"],"pagination":["e70525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12848849"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(3)"],"pubmed_abstract":["Background and aims
Immune-mediated bile duct injury is the primary histological feature of autoimmune cholestatic liver diseases. Macrophages, the most abundant immune cell population in the liver, have been postulated to play a critical role in biliary repair. However, it is unclear whether activated macrophages interact with injured biliary epithelial cells.Methods
We evaluated the expression of insulin-like growth factor-binding protein 4 (IGFBP4) in primary monocytes, MDMΦ, serum, and liver tissue sections from a total of 292 samples from PBC, PSC, and healthy controls using RNA-sequencing, ELISA, and immunohistochemistry analysis. The signal pathways involved in the effect of IGFBP4 in human intrahepatic biliary epithelial cells were examined by phospho-kinase arrays."],"journal":["Liver international : official journal of the International Association for the Study of the Liver"],"pubmed_title":["IGFBP4 is a Metric for Primary Biliary Cholangitis and Attenuates Biliary Epithelial Cell Injury."],"pmcid":["PMC12848849"],"funding_grant_id":["RO1 DK123262","82202000","2018","R01 DK123262"],"pubmed_authors":["Leung PSC","Ansari AA","Yang D","Zhou X","Cheng Z","Ridgway WM","Zhang W","Bowlus CL","Tanaka T","Invernizzi P","Tsuneyama K","Shao S","Gershwin ME"],"additional_accession":[]},"is_claimable":false,"name":"IGFBP4 is a Metric for Primary Biliary Cholangitis and Attenuates Biliary Epithelial Cell Injury.","description":"Background and aims
Immune-mediated bile duct injury is the primary histological feature of autoimmune cholestatic liver diseases. Macrophages, the most abundant immune cell population in the liver, have been postulated to play a critical role in biliary repair. However, it is unclear whether activated macrophages interact with injured biliary epithelial cells.Methods
We evaluated the expression of insulin-like growth factor-binding protein 4 (IGFBP4) in primary monocytes, MDMΦ, serum, and liver tissue sections from a total of 292 samples from PBC, PSC, and healthy controls using RNA-sequencing, ELISA, and immunohistochemistry analysis. The signal pathways involved in the effect of IGFBP4 in human intrahepatic biliary epithelial cells were examined by phospho-kinase arrays.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-06-09T05:44:13.302Z","creation":"2026-06-09T03:07:44.372Z"},"accession":"S-EPMC12848849","cross_references":{"pubmed":["41603281"],"doi":["10.1111/liv.70525"]}}