{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Moscoso A"],"funding":["NCATS NIH HHS","NIBIB NIH HHS","European Research Council","NIA NIH HHS","NCRR NIH HHS","NIAID NIH HHS","RRD VA","NIMH NIH HHS","NIDCD NIH HHS","NINDS NIH HHS","Wellcome Trust","NIH HHS"],"pagination":["229-242"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12848857"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["334(3)"],"pubmed_abstract":["<h4>Importance</h4>Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer disease (AD).<h4>Objective</h4>To provide estimates of the frequency of tau PET positivity and its associated risk of clinical outcomes.<h4>Design, setting, and participants</h4>Longitudinal study using data pooled from 21 cohorts, comprising a convenience sample of 6514 participants from 13 countries, collected between January 2013 and June 2024. Cognitively unimpaired individuals and patients with a clinical diagnosis of mild cognitive impairment (MCI), AD dementia, or other neurodegenerative disorders were included.<h4>Exposures</h4>Tau PET with flortaucipir F 18, amyloid-β (Aβ) PET, and clinical examinations. Tau PET scans were visua"],"journal":["JAMA"],"pubmed_title":["Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity."],"pmcid":["PMC12848857"],"funding_grant_id":["R01 AG058724","P30 AG028283","R56 AG045571","P30 AG053760","U01 AG057195","R01 AG079142","P50 AG047266","P20 AG068053","R35 AG072362","P30 AG066444","P30 AG019610","R01 AG062276","P30 AG072958","P30 AG072959","P50 AG047270","P30 AG066546","R01 AG056031","P01 AG036694","P50 MH071616","U19 NS120384","U24 AG067418","U24 RR021382","R01 AG069453","P30 AG072946","P20 MH071616","P01 AG003991","P30 AG072947","R01 AG052560","P30 AG010133","220258","101096455","P30 AG072931","P20 AG068077","R01 AG067781","R01 DC008552","P30 AG010129","R01 NS075075","R56 AG074321","R01 AG054110","R01 AG056531","R01 AG019771","R01 AG056258","F30 AG067677","P50 AG016574","P30 AG066530","P20 AG068082","P50 AG016573","R01 AG077444","P30 AG062677","P50 AG005142","P30 AG066514","P30 AG066515","P30 AG066518","P30 AG062715","P30 AG066519","R01 AG053993","R01 AG043434","R56 AG057195","U19 AG073153","R01 AG053509","R01 AG081394","R01 AG045571","R01 AG061788","R01 AG068338","U19 AG063911","P50 AG008702","P30 AG062428","P30 AG062421","P30 AG062422","R01 AG073235","P30 AG010161","P30 AG066506","P30 AG066507","UL1 TR000448","I01 RX001534","P30 AG066508","P30 AG062429","P30 AG066509","R01 AG021910","S10 OD026738","P30 AG066511","P30 AG066512","U24 AG072122","R01 AG083740","P20 AG068024","P30 AG013846","P30 AG008017","P50 AG033514","U01 AG006786","P30 AG072980","R01 AG034570","P50 AG047366","P30 AG072975","P30 AG066462","P30 AG072976","P30 AG072977","R35 AG072262","P30 AG072972","P30 AG066468","P30 AG072973","R01 EB009352","P30 AG072978","P30 AG072979","R01 AG079280","P30 AG013854","R01 AG055005","I21 RX001381","F31 AG067677","P50 AG005136","P30 AG035982","P50 AG005133","P30 NS098577","U01 AG024904","P01 AG026276"],"pubmed_authors":["Chhatwal JP","Pogossova G","Crawford K","Gervais V","Bernard M","Lafaille-Magnan ME","Poirier J","Aguiar P","Spreng N","Carrillo M","Okonkwo O","DeCarli C","Gunter J","Frisoni GB","Figurski M","Riddle M","Frenette J","Rogalski E","Couture D","Hoge R","Montine T","Taylor-Reinwald L","Mathis C","Fonov V","Vogel J","Kat J","Hansson O","Nudelman K","Duara R","Labonte A","Yuschkevich PA","Mohammediyan B","Sepulcre J","Rioux P","Dage J","Toga A","Tullo S","Lois Gomez C","Gonzalez H","Fletcher E","Mathieu A","Kazazian C","Silva-Rodriguez J","Musiek E","Seo SW","Salloway S","Schwarz C","Miller G","Malone I","Gatchel J","Carrier CE","Turner RS","Teigner E","Yu E","Neu S","Pardilla-Delgado E","Quiroz Y","Khachaturian Z","Jones D","Drzezga A","Neuhaus J","Newell K","Johnson KA","Conti C","Cheewakriengkrai L","Nir TM","Risacher SL","Rajah N","Ferdinand F","Appleby M","Buckley R","Dadar M","Coomans EM","Frappier J","Dickerson B","Aisen P","Clanton T","Camacho V","Anthal E","Soleimani-Meigooni DN","Craft S","Kirby K","Murray ME","Grinberg LT","Rowe JB","Guzman-Velez E","Debacker C","Hammers D","Eloyan A","Dansereau C","Soucy JP","Brum WS","Bedetti C","Zimmerman C","Vachon-Presseau E","Rentz D","Malpetti M","Saint-Fort EF","Multhaup G","Apostolova LG","Brandt J","Borowski B","Fockler J","Landau S","Raghavan S","Kukull WA","Ozlen H","Koeppe RA","Ashford M","Jutten R","El-Khoury R","Reynolds G","Chen Y","Green RC","Reiman EM","Evans A","Duclair G","Oaoo K","Chen K","Tardif C","Near J","Barnes L","Desautels R","Foroud T","Chen SR","Petersen RC","Dufour M","Hergesheimer L","Daoust LA","Fleisher A","Gagliardi G","Eisenberg M","Cuello C","Masdeu J","Veitch D","Bernhardt H","Nho K","Barkun A","Skylar-Scott I","Theroux L","Tuwaig M","Franklin E","Farzin S","Ryan L","Rodriguez-Fonseca O","Geddes M","Faubert AM","Choe M","Dauar-Tedeschi M","McSweeney M","Coker G","Reid R","Nosheny R","Adegoke O","Madjar C","Chapleau M","Courcot B","Sager M","Honig LS","Rafii M","Morris J","Remz J","Flenniken D","Savard M","Jackson J","Saykin AJ","van Essen M","Mendez M","Moore S","Atri A","Jean G","Gessert D","Faber K","Thompson P","Breitner J","Dubuc S","Sylvain E","Onyike CU","Meyer PO","Collins L","Vemuri P","Fox NC","Shen L","Pruessner J","Touroutoglou A","Clark D","Wolk DA","Gordon R","Tosun-Turgut D","Senjem M","Blacker D","Thal L","Koeppe R","Jin C","Wan K","O'Brien JT","Silverberg N","Masliah E","Salazar J","Knaack A","Shaffer E","Pizzola J","Giles R","Fontaine D","Kostopoulos P","Ghetti B","Ossenkoppele R","Vila-Castelar C","Page V","Ituria-Medina Y","Jacobs H","Walter S","Verfaillie S","Knopman D","Venugopalan V","Johnson ECB","Kramer J","Thangarajah M","Yun J","Carmo L","Cairns NJ","Toga AW","Petkova M","Legarde J","Masterman D","Villeneuve S","Leoutsakos JM","Thomas R","Cabrera Y","Pascoal T","Benbouhoud F","Jones DT","Garibotto V","Perrin RJ","Mayrand G","Jagust WJ","Mahboubi P","Price J","LaMontagne PJ","Foroud TM","Yang HS","Rosa-Neto P","Greco C","Tam A","Pichet Binette A","Raman R","Bohbot V","St-Onge F","Leblond-Baccichet G","Gagne G","Scholl M","Peretti D","Sperling RA","Pishnamazi M","Orban P","Perissinotti A","Tabrizi S","Householder E","Sha S","Lee T","Kobe T","Forghanian-Arani A","Gauthier S","Toussaint PJ","Beckett L","Jack CR","Day GS","Salaciak A","Taurone A","Graff-Radford NR","A Lie MJ","Wang S","Amariglio RE","Miron J","Vallee I","Grothe MJ","Lepage C","Maltais JR","Bailly J","Wilmes K","Tremblay-Mercier J","Ho C","Heeman F","Mathotaarachchi S","Michaud D","Schultz A","Dickerson BC","Newbold-Fox H","Weiner MW","Potter W","Ducharme S","Donovan N","Costoya-Sanchez A","Korecka M","Beaudry T","Harvey D","Bellec P","Hudon L","Ward C","Womack K","van de Giessen EM","Nilsson N","Picard C","Vannini P","Das S","Chakravarty M","Mainta I","Grant I","Etienne P","Maillet D","Kormos A","Farrell M","Nair V","Ribaldi F","Leppert I","Schultz S","Pontecorvo MJ","La Joie R","Rabinovici GD","Hsiao JK","Prokopiou P","Jahanshad N","Gu Y","Trojanowki JQ","Dea D","Bischof GN","Marshall G","Morris JC","Donohue M","Jimenez G","Wingo TS","Smith S","Smith R","Thomopoulos SI","Boutin S","PREVENT-AD Research Group, the Harvard Aging Brain Study, the LEADS Consortium, and the Alzheimer’s Disease Neuroimaging Initiative","Tariot P","Moscoso A","Mahar L","Shaw LM","Gonneaud J","Polsinelli A","Kantarci K"],"additional_accession":[]},"is_claimable":false,"name":"Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity.","description":"<h4>Importance</h4>Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer disease (AD).<h4>Objective</h4>To provide estimates of the frequency of tau PET positivity and its associated risk of clinical outcomes.<h4>Design, setting, and participants</h4>Longitudinal study using data pooled from 21 cohorts, comprising a convenience sample of 6514 participants from 13 countries, collected between January 2013 and June 2024. Cognitively unimpaired individuals and patients with a clinical diagnosis of mild cognitive impairment (MCI), AD dementia, or other neurodegenerative disorders were included.<h4>Exposures</h4>Tau PET with flortaucipir F 18, amyloid-β (Aβ) PET, and clinical examinations. Tau PET scans were visua","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-06-11T05:38:24.383Z","creation":"2026-06-11T03:08:06.012Z"},"accession":"S-EPMC12848857","cross_references":{"pubmed":["40522652"],"doi":["10.1001/jama.2025.7817"]}}