{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(7)"],"submitter":["Pervez Lali S"],"pubmed_abstract":["This study explores the enhancement of oral bioavailability, dissolution rate, and solubility of weakly water-soluble fluoroquinolone antibiotic, ofloxacin (OFL), by solid dispersion (SD) formulation prepared using the spray drying technique. Hydrophilic polymers; hydroxypropyl methylcellulose (HPMC) and xanthan gum (XNG) were used as carriers. FT-IR spectroscopy indicated hydrogen bonding between OFL and the polymer's backbone. DSC and PXRD analyses revealed a transformation from the crystalline to the amorphous state. SEM images revealed reduced particle size and changed surface morphology, which are favorable for solubility improvement. The <i>in vitro</i> drug release studies, performed in simulated gastric conditions (pH 6.8) showed a significant improvement in the drug release, 97.88% and 82.34% for HPMC-based (O-H) and XNG-based (O-X) SDs, respectively, as compared to only 59.2% for unprocessed OFL. Further, <i>in vivo</i>, kinetics reported in a validated HPLC-UV method in rabbits showed an impressive <i>C</i> <sub>max</sub> (O-H: 4.33 µg mL<sup>-1</sup>; O-X: 4.12 µg mL<sup>-1</sup>; OFL: 1.8 µg mL<sup>-1</sup>) and  prolonged <i>t</i> <sub>1</sub>/<sub>2</sub> (8 h <i>vs.</i> 5 h). Thus demonstrating a significant enhancement in bioavailability in the rabbit model. The SDs produced with HPMC and XNG represent a promising strategy to improve the solubility and <i>in vivo</i> performance of OFL, which may translate to improved therapeutic efficacy."],"journal":["RSC advances"],"pagination":["6048-6060"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12848879"],"repository":["biostudies-literature"],"pubmed_title":["Engineering ofloxacin bioavailability through spray-dried HPMC and xanthan gum-based solid dispersions: enhanced solubility and therapeutic efficacy."],"pmcid":["PMC12848879"],"pubmed_authors":["Shaaban IA","Sher M","Abbas A","Hussain MA","Naeem-Ul-Hassan M","Haseeb MT","Khaled Sendy B","Pervez Lali S","Fatima A","Alhoshani FM"],"additional_accession":[]},"is_claimable":false,"name":"Engineering ofloxacin bioavailability through spray-dried HPMC and xanthan gum-based solid dispersions: enhanced solubility and therapeutic efficacy.","description":"This study explores the enhancement of oral bioavailability, dissolution rate, and solubility of weakly water-soluble fluoroquinolone antibiotic, ofloxacin (OFL), by solid dispersion (SD) formulation prepared using the spray drying technique. Hydrophilic polymers; hydroxypropyl methylcellulose (HPMC) and xanthan gum (XNG) were used as carriers. FT-IR spectroscopy indicated hydrogen bonding between OFL and the polymer's backbone. DSC and PXRD analyses revealed a transformation from the crystalline to the amorphous state. SEM images revealed reduced particle size and changed surface morphology, which are favorable for solubility improvement. The <i>in vitro</i> drug release studies, performed in simulated gastric conditions (pH 6.8) showed a significant improvement in the drug release, 97.88% and 82.34% for HPMC-based (O-H) and XNG-based (O-X) SDs, respectively, as compared to only 59.2% for unprocessed OFL. Further, <i>in vivo</i>, kinetics reported in a validated HPLC-UV method in rabbits showed an impressive <i>C</i> <sub>max</sub> (O-H: 4.33 µg mL<sup>-1</sup>; O-X: 4.12 µg mL<sup>-1</sup>; OFL: 1.8 µg mL<sup>-1</sup>) and  prolonged <i>t</i> <sub>1</sub>/<sub>2</sub> (8 h <i>vs.</i> 5 h). Thus demonstrating a significant enhancement in bioavailability in the rabbit model. The SDs produced with HPMC and XNG represent a promising strategy to improve the solubility and <i>in vivo</i> performance of OFL, which may translate to improved therapeutic efficacy.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-11T06:01:21.99Z","creation":"2026-06-11T03:12:01.728Z"},"accession":"S-EPMC12848879","cross_references":{"pubmed":["41613229"],"doi":["10.1039/d5ra06222e"]}}