{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boroumand-Jazi R"],"funding":["Deutsche Forschungsgemeinschaft","Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)"],"pagination":["e70123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12848907"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(2)"],"pubmed_abstract":["Preliminary animal and human studies have shown that blood dihydrotestosterone concentrations are increased in males with alcohol use disorder, and 5α-reductase inhibitors, which decrease dihydrotestosterone concentrations, reduce alcohol consumption. To gain mechanistic insight, we studied the effects of reduced dihydrotestosterone concentrations following pharmacological 5α-reductase inhibition on alcohol cue-elicited brain activity and alcohol craving in males with problematic alcohol use. To this end, this randomized, placebo-controlled, crossover challenge experiment investigated associations between dihydrotestosterone concentrations and brain functional magnetic resonance imaging (fMRI) activity during exposure to visual alcohol cues and alcohol craving following a single dose of 5 "],"journal":["Addiction biology"],"pubmed_title":["Dihydrotestosterone and Finasteride Effects on Alcohol Cue-Elicited Brain Activity in Males With Heavy Episodic Drinking."],"pmcid":["PMC12848907"],"funding_grant_id":["402170461 – TRR265","402170461 - TRR265"],"pubmed_authors":["Tan H","Muhle C","Gerhardt S","Bach P","Beck A","Boroumand-Jazi R","Lenz B","Sommer WH","Kundlacz M","Muller CP","Reichl M","Hoffmann S","Wenger LP","Vollstadt-Klein S","Kiefer F","Reinhard I"],"additional_accession":[]},"is_claimable":false,"name":"Dihydrotestosterone and Finasteride Effects on Alcohol Cue-Elicited Brain Activity in Males With Heavy Episodic Drinking.","description":"Preliminary animal and human studies have shown that blood dihydrotestosterone concentrations are increased in males with alcohol use disorder, and 5α-reductase inhibitors, which decrease dihydrotestosterone concentrations, reduce alcohol consumption. To gain mechanistic insight, we studied the effects of reduced dihydrotestosterone concentrations following pharmacological 5α-reductase inhibition on alcohol cue-elicited brain activity and alcohol craving in males with problematic alcohol use. To this end, this randomized, placebo-controlled, crossover challenge experiment investigated associations between dihydrotestosterone concentrations and brain functional magnetic resonance imaging (fMRI) activity during exposure to visual alcohol cues and alcohol craving following a single dose of 5 ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-10T08:57:48.599Z","creation":"2026-06-10T03:11:29.421Z"},"accession":"S-EPMC12848907","cross_references":{"pubmed":["41603384"],"doi":["10.1111/adb.70123"]}}