biostudies-literatureBoroumand-Jazi RDeutsche ForschungsgemeinschaftDeutsche Forschungsgemeinschaft (DFG, German Research Foundation)e70123https://www.ebi.ac.uk/biostudies/studies/S-EPMC12848907biostudies-literatureUnknown31(2)Preliminary animal and human studies have shown that blood dihydrotestosterone concentrations are increased in males with alcohol use disorder, and 5α-reductase inhibitors, which decrease dihydrotestosterone concentrations, reduce alcohol consumption. To gain mechanistic insight, we studied the effects of reduced dihydrotestosterone concentrations following pharmacological 5α-reductase inhibition on alcohol cue-elicited brain activity and alcohol craving in males with problematic alcohol use. To this end, this randomized, placebo-controlled, crossover challenge experiment investigated associations between dihydrotestosterone concentrations and brain functional magnetic resonance imaging (fMRI) activity during exposure to visual alcohol cues and alcohol craving following a single dose of 5 Addiction biologyDihydrotestosterone and Finasteride Effects on Alcohol Cue-Elicited Brain Activity in Males With Heavy Episodic Drinking.PMC12848907402170461 – TRR265402170461 - TRR265Tan HMuhle CGerhardt SBach PBeck ABoroumand-Jazi RLenz BSommer WHKundlacz MMuller CPReichl MHoffmann SWenger LPVollstadt-Klein SKiefer FReinhard IfalseDihydrotestosterone and Finasteride Effects on Alcohol Cue-Elicited Brain Activity in Males With Heavy Episodic Drinking.Preliminary animal and human studies have shown that blood dihydrotestosterone concentrations are increased in males with alcohol use disorder, and 5α-reductase inhibitors, which decrease dihydrotestosterone concentrations, reduce alcohol consumption. To gain mechanistic insight, we studied the effects of reduced dihydrotestosterone concentrations following pharmacological 5α-reductase inhibition on alcohol cue-elicited brain activity and alcohol craving in males with problematic alcohol use. To this end, this randomized, placebo-controlled, crossover challenge experiment investigated associations between dihydrotestosterone concentrations and brain functional magnetic resonance imaging (fMRI) activity during exposure to visual alcohol cues and alcohol craving following a single dose of 5 2026-01-01T00:00:00Z2026 Feb2026-06-10T08:57:48.599Z2026-06-10T03:11:29.421ZS-EPMC128489074160338410.1111/adb.70123