biostudies-literatureUnknown25Leiter LA<h4>Background and aims</h4>Improving care of patients with hyperlipidemia requires an understanding of the barriers physicians perceive in prescribing low-density lipoprotein cholesterol (LDL-C)-lowering therapies. This study explores physicians' perceptions of time and resource burdens, identify perceived patient adherence barriers, and examine factors influencing physicians' decision-making in LDL-C management.<h4>Methods</h4>This is a non-interventional, cross-sectional, online survey of US-based primary care practitioners (PCP) and cardiologists who recommended or provided lipid-lowering therapy (LLT) to ≥50 adults per month, practiced for ≥2 years, and completed the survey in English. The survey comprised multiple-choice, constant sum, and numerical questions about physician decisionAmerican journal of preventive cardiology101386https://www.ebi.ac.uk/biostudies/studies/S-EPMC12849048biostudies-literatureOptimizing low-density lipoprotein cholesterol (LDL-C) management - a US physician survey of barriers and burdens.PMC12849048Bash LDBaum SJSchmier JKSimpson RJKarmarkar TJayade SPRoney KCExter JLeiter LAfalseOptimizing low-density lipoprotein cholesterol (LDL-C) management - a US physician survey of barriers and burdens.<h4>Background and aims</h4>Improving care of patients with hyperlipidemia requires an understanding of the barriers physicians perceive in prescribing low-density lipoprotein cholesterol (LDL-C)-lowering therapies. This study explores physicians' perceptions of time and resource burdens, identify perceived patient adherence barriers, and examine factors influencing physicians' decision-making in LDL-C management.<h4>Methods</h4>This is a non-interventional, cross-sectional, online survey of US-based primary care practitioners (PCP) and cardiologists who recommended or provided lipid-lowering therapy (LLT) to ≥50 adults per month, practiced for ≥2 years, and completed the survey in English. The survey comprised multiple-choice, constant sum, and numerical questions about physician decision2026-01-01T00:00:00Z2026 Feb2026-06-16T03:12:49.173Z2026-06-16T03:07:20.769ZS-EPMC128490484161335210.1016/j.ajpc.2025.101386